Proton radiotherapy

RADIATION18 trials

Conditions

Anal Cancer Squamous CellArteriovenous MalformationAstrocytomaBrain TumorBreast CancerBreast NeoplasmBreast TumorCancer of the Breast

Phase 1

Definitive Proton Radiotherapy Combined With Chemotherapy and Immunotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Phase I Clinical Study

Not yet recruitingNCT07034118

Anhui Provincial HospitalEsophageal Carcinoma

Start: 2025-08-01End: 2028-08-31Target: 23Updated: 2025-06-24

Phase 2

Proton Radiotherapy for Patients With Non-Small Cell Lung Cancer (NSCLC)

CompletedNCT00495040

M.D. Anderson Cancer CenterLung Cancer

Start: 2006-05-04End: 2017-06-14Updated: 2019-01-14

Concurrent Proton and Chemotherapy in Locally Advanced Stage IIIA/B Non-Small Cell Lung Cancer (NSCLC)

CompletedNCT00495170

M.D. Anderson Cancer CenterLung Cancer

Start: 2006-04-14End: 2017-06-14Updated: 2019-02-06

Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation

CompletedNCT01288235

Massachusetts General HospitalAstrocytoma, Brain Tumor, Ependymoma +2

Start: 2011-02-28End: 2016-09-30Updated: 2025-06-03

Proton Radiation for Stage II/III Breast Cancer

Active, not recruitingNCT01758445

Proton Collaborative GroupBreast Cancer, Breast Neoplasm, Breast Tumor +1

Start: 2013-02-28End: 2032-01-31Target: 220Updated: 2025-09-04

Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer

RecruitingNCT01766297

Proton Collaborative GroupBreast Cancer, Breast Neoplasm, Breast Tumor +1

Start: 2013-02-28End: 2035-01-31Target: 132Updated: 2025-09-09

Proton Radiotherapy for Primary Central Nervous System Tumours in Adults

RecruitingNCT02797366

Uppsala UniversityArteriovenous Malformation, Central Nervous System Tumour

Start: 2015-08-31End: 2030-07-31Target: 500Updated: 2016-06-13

Atezolizumab and Bevacizumab With Proton Radiotherapy for Unresectable Hepatocellular Carcinoma

RecruitingNCT06133062

Chang Gung Memorial HospitalHepatocellular Carcinoma Non-resectable

Start: 2023-11-16End: 2030-09-30Target: 45Updated: 2026-03-20

The Clinical Study of Post-operative Proton Radiotherapy for Thymus Tumor

RecruitingNCT06311968

Jian ChenProton Radiotherapy, Radiation Toxicity, Thymus Epithelial Tumor

Start: 2024-05-06End: 2027-02-28Target: 55Updated: 2025-06-13

A Prospective Cohort Study of Proton and Photon Therapy for Left-sided Breast Cancer.

RecruitingNCT06677879

Shanghai Proton and Heavy Ion CenterBreast Cancer

Start: 2024-08-01End: 2028-07-31Target: 780Updated: 2025-05-30

Proton Radiotherapy Plus Tremelimumab/Durvalumab for BCLC Stage B and C HCC

RecruitingNCT06999694

Chang Gung Memorial HospitalDurvalumab, HCC - Hepatocellular Carcinoma, Proton Radiotherapy +1

Start: 2025-05-22End: 2033-05-31Target: 45Updated: 2025-09-10

Phase 3

Proton Radiotherapy Versus Radiofrequency Ablation for Patients With Medium or Large Hepatocellular Carcinoma

NCT02640924

Chang Gung Memorial HospitalCarcinoma, Hepatocellular

Start: 2016-01-31End: 2021-12-31Target: 166Updated: 2016-03-21

PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy

RecruitingNCT05055648

University of AarhusEsophageal Cancer, Proton Therapy, Radiotherapy +1

Start: 2022-05-01End: 2032-12-01Target: 396Updated: 2024-12-17

Unknown Phase

Proton Radiotherapy for Recurrent Tumors

CompletedNCT01126476

Abramson Cancer Center at Penn MedicineTumors

Start: 2010-02-28End: 2020-04-30Target: 24Updated: 2020-04-24

Carbon Ion Radiotherapy for Primary Glioblastoma

CompletedNCT01165671

University Hospital HeidelbergPrimary Glioblastoma

Start: 2010-07-31End: 2015-01-31Updated: 2020-04-03

Proton Versus Photon Therapy in Anal Squamous Cell Carcinoma

RecruitingNCT04462042

Umeå UniversityAnal Cancer Squamous Cell

Start: 2021-04-07End: 2031-03-28Target: 100Updated: 2025-04-03

DAHANCA 35: Proton Versus Photon Therapy for Head-neck Cancer

NCT04607694

Danish Head and Neck Cancer GroupHead-and-neck Cancer

Start: 2020-10-09End: 2025-09-30Target: 600Updated: 2020-10-29

Feasibility of Patient Selection and Treatment of Head-neck Cancer With Proton Therapy in Denmark

Active, not recruitingNCT05423704

Danish Head and Neck Cancer GroupHead-and-neck Cancer

Start: 2019-05-20End: 2026-05-14Updated: 2022-06-21

Related Papers

Considerations for study design in the DAHANCA 35 trial of protons versus photons for head and neck cancer.

2023-10-2114 citations

Proton therapy planning and image-guidance strategies within a randomized controlled trial for high-risk prostate cancer

Clinical and Translational Radiation Oncology2023-04-256 citations

Prospective trial of proton reirradiation of locally recurrent esophageal cancer.

Journal of Clinical Oncology2014-01-202 citations

Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: the CLEOPATRA trial.

2010-09-0667 citations