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Prospera

DIAGNOSTIC_TEST5 trials

Sponsors

Natera, Inc., University of Alberta

Conditions

Heart TransplantHeart Transplant RejectionKidney Transplant RejectionLung Transplant Rejection

Unknown Phase

The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive)
Active, not recruitingNCT04091984
Natera, Inc.Kidney Transplant Rejection
Start: 2019-11-06End: 2027-10-01Target: 5000Updated: 2024-08-06
Trifecta-Kidney cfDNA-MMDx Study
RecruitingNCT04239703
University of AlbertaKidney Transplant Rejection
Start: 2019-12-01End: 2029-12-01Target: 300Updated: 2026-06-02
Trifecta-Heart cfDNA-MMDx Study
RecruitingNCT04707872
University of AlbertaHeart Transplant Rejection
Start: 2021-06-01End: 2028-07-01Target: 300Updated: 2026-06-02
LAMBDA 002 (Lung Registry) Study
Active, not recruitingNCT05170425
Natera, Inc.Lung Transplant Rejection
Start: 2022-11-04End: 2027-05-31Updated: 2025-05-22
Development of Non-invasive Cell-free DNA to Supplant Invasive Biopsy in Heart Transplantation
CompletedNCT05309382
Natera, Inc.Heart Transplant
Start: 2022-12-12End: 2024-10-02Updated: 2024-10-29

Related Papers

A Two-Threshold dd-cfDNA Algorithm Improves Detection of Molecular Rejection in Heart Transplantation.
2026-06-22
Defining the relationships among four tests for assessing antibody-mediated rejection in heart transplants in a prospective, observational study.
2025-11-132 citations
Improving the histologic detection of donor-specific antibody-negative antibody-mediated rejection in kidney transplants
American Journal of Transplantation2025-08-233 citations
Defining Relationships Among Tests for Kidney Transplant Antibody-Mediated Rejection.
2025-06-172 citations
A cross-sectional study of the role of epithelial cell injury in kidney transplant outcomes.
2025-04-15
Elevation of Donor-derived Cell-free DNA Before Biopsy-proven Rejection in Kidney Transplant
Transplantation2024-04-1032 citations
Comparing Plasma Donor–derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart Study
Transplantation2024-03-2817 citations
Distinct Molecular Processes Mediate Donor-derived Cell-free DNA Release From Kidney Transplants in Different Disease States
Transplantation2023-12-2719 citations
Antibody-mediated Rejection Without Detectable Donor-specific Antibody Releases Donor-derived Cell-free DNA: Results From the Trifecta Study
Transplantation2022-10-0358 citations
427.4: Combining Donor Derived Cell-Free DNA Fraction and Quantity To Detect Kidney Transplant Rejection Using Molecular Diagnoses
Transplantation2022-09-01
Combining Donor-derived Cell-free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology as Confirmation
Transplantation2022-06-2954 citations
The Trifecta Study: Comparing Plasma Levels of Donor-derived Cell-Free DNA with the Molecular Phenotype of Kidney Transplant Biopsies
Journal of the American Society of Nephrology2022-01-20113 citations