Prophylactic Cranial Irradiation
Sponsors
Children's Oncology Group, Alberta Health services, M.D. Anderson Cancer Center, Radiation Therapy Oncology Group, Zhejiang Cancer Hospital
Conditions
Acute Lymphoblastic LeukemiaAdult B Acute Lymphoblastic LeukemiaBrain MetastasisBreast CancerChemoradiotherapyChildhood B Acute Lymphoblastic LeukemiaExtensive Stage Lung Small Cell CarcinomaExtensive-stage Small Cell Lung Cancer
Phase 1
Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)
CompletedNCT00866307
Start: 2009-02-23End: 2021-03-31Updated: 2021-04-27
Prophylactic Cranial Irradiation in Patients With HER-2-Positive Metastatic Breast Cancer
CompletedNCT00916877
Start: 2009-11-30End: 2011-03-31Target: 110Updated: 2011-08-08
Neuroprotective Effects of Lithium in Patients With Small Cell Lung Cancer Undergoing Radiation Therapy to the Brain
CompletedNCT01553916
Start: 2012-04-26End: 2017-06-05Updated: 2018-07-05
Phase 2
Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors
CompletedNCT00984997
Start: 1993-10-31End: 2015-06-30Updated: 2016-06-30
Radiation Therapy in Treating Patients With Extensive Stage Small Cell Lung Cancer
CompletedNCT01055197
Start: 2010-03-31End: 2016-12-31Updated: 2018-12-12
Temozolomide as Maintenance Therapy Following Induction Chemotherapy in Extensive Stage Small Cell Lung Cancer
NCT02772107
Start: 2015-12-31End: 2018-01-31Target: 132Updated: 2016-05-17
Prophylactic cranial irradiation with hippocampal sparing technique in small cell lung cancer patients
RecruitingTCTR20200725001
Start: 2018-10-26Target: 25Updated: 2026-08-03
Concurrent Chemoradiotherapy Combined With Toripalimab and Surufatinib in the Treatment of Limited-Stage Small Cell Lung Cancer
RecruitingNCT06719700
Start: 2024-11-30End: 2028-11-29Target: 47Updated: 2026-03-03
Phase 3
Prophylactic Cranial Irradiation in Erlotinib/Gefitinib-responders With Non-small Cell Lung Cancer (NSCLC) (RT1001)
NCT01158170
Start: 2010-06-30End: 2013-12-31Target: 200Updated: 2010-07-08
Prophylactic Cranial Irradiation (PCI) vs Observation in Stage III NSCLC
CompletedNCT01282437
Start: 2009-01-31End: 2015-03-31Updated: 2015-04-10
S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer
Active, not recruitingNCT04155034
Start: 2020-05-04End: 2029-11-15Target: 668Updated: 2026-06-11
PCI for Patients With ES-SCLC After RCT:a Prospective Randomized Study
NCT04535739
Start: 2019-07-01End: 2022-06-30Target: 414Updated: 2020-09-02
Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy
RecruitingNCT04829708
Start: 2021-04-26End: 2028-04-15Target: 534Updated: 2021-04-29
Unknown Phase
Prophylactic Cranial Irradiation in Patients With Lung Adenocarcinoma With High Risk of Brain Metastasis
CompletedNCT01603849
Start: 2012-05-31End: 2020-07-31Updated: 2023-04-27
PCI in Advanced Triple Negative Breast Cancer Patients Who Response to 1st Line Chemotherapy
NCT02448576
Start: 2017-08-31End: 2025-08-31Target: 326Updated: 2017-06-01
Neoadjuvant Therapy Combined With Radical Surgery for the Treatment of Small Cell Lung Cancer (SCLC) in II and IIIA Stage
NCT03523234
Start: 2018-10-31End: 2023-07-31Target: 300Updated: 2018-09-05
PRophylactic Cerebral Irradiation or Active MAgnetic Resonance Imaging Surveillance in Small-cell Lung Cancer Patients (PRIMALung Study)
RecruitingNCT04790253
Start: 2022-10-27End: 2028-04-30Target: 600Updated: 2023-11-03
Prophylactic Cranial Irradiation in Extensive-stage Small Cell Lung Cancer
NCT04947774
Start: 2020-11-01End: 2022-10-31Target: 100Updated: 2021-09-22
PCI and Brain MRI Follow-up vs Brain MRI Follow-up Alone in Limited-stage SCLC Patients
RecruitingNCT05651802
Start: 2023-01-01End: 2026-06-30Target: 220Updated: 2023-12-19