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Problem Management Plus

BEHAVIORAL8 trials

Sponsors

University of Zurich, RAND, George Washington University, Kenyatta University department of Counseling Psychology

Conditions

AnxietyCommon Mental Health ProblemsCommon mental disordersDepressionDepressive DisorderDistressFunctional DisabilitiesMental and Behavioural Disorders Pregnancy and Childbirth

Phase 1

Adaptation and pilot evaluation of Problem Management Plus Intervention(PM+) to address psychological distress caused by Covid-19 and other adversities amongst an amaXhosa sample in the Eastern Cape, South Africa
Active, not recruitingPACTR202110484536189
Common mental disorders
Start: 2023-06-01Target: 60Updated: 2026-08-03

Phase 3

Effectiveness of Problem Management Plus Complementary Intervention on Quality of Life of among Female Genital Fistula Survivors of Selected Counties in Kenya
Active, not recruitingPACTR202605542706008
Kenyatta University department of Counseling PsychologyMental and Behavioural Disorders Pregnancy and Childbirth
Start: 2023-06-04Target: 172Updated: 2026-08-03

Phase 4

Integrating a Stepped Care Model of Screening and Treatment for Depression Into Malawi's National HIV Care Delivery Platform
CompletedNCT04777006
RANDDepressive Disorder
Start: 2021-09-01End: 2025-06-30Updated: 2026-06-09

Unknown Phase

Scaling-up Psychological Interventions With Syrian Refugees in Switzerland
CompletedNCT03830008
University of ZurichAnxiety, Common Mental Health Problems, Depression +4
Start: 2018-12-21End: 2020-03-20Updated: 2021-02-08
Scaling-up Psychological Interventions With Syrian Refugees in Switzerland (STRENGTHS_CH): RCT
CompletedNCT04574466
University of ZurichAnxiety, Common Mental Health Problems, Depression +4
Start: 2020-08-25End: 2022-12-31Updated: 2023-05-09
REstoring Mental Health Through COmmUnity-based Psychological Services in New York City
CompletedNCT04913766
George Washington UniversityAnxiety, Depression, Psychological Distress +1
Start: 2022-10-25End: 2026-02-09Updated: 2026-05-28
Feasibility and Acceptability of BRIGHT
CompletedNCT06397105
University of ZurichPsychological Distress, PTSD, Trauma, Psychological
Start: 2024-10-15End: 2025-12-19Updated: 2026-04-20
Boosting Refugee Integration Through Psychological Intervention
RecruitingNCT06776523
University of ZurichCommon Mental Health Problems, Psychological Distress, PTSD +1
Start: 2025-01-16End: 2027-09-01Target: 1200Updated: 2026-04-27

Related Papers

Study protocol of a pilot randomised controlled trial examining massed culturally adapted Problem Management Plus (PM +) in South Africa.
2026-01-27
Provider perceptions and experiences integrating depression treatment into chronic healthcare services in Neno District, Malawi: a qualitative study
BMC Health Services Research2025-12-10
Cost analysis of integrating depression treatment into chronic care in Malawi: evidence from a cluster randomised controlled trial.
2025-10-071 citations
Patient perspectives on group problem management plus for adults with major depressive disorder in rural Malawi
Global Health Action2025-05-091 citations
Effectiveness, cost-effectiveness, and positive externalities of integrated chronic care for adults with major depressive disorder in Malawi (IC3D): a stepped-wedge, cluster-randomised, controlled trial.
2024-10-307 citations
Depressive disorder at the household level: prevalence and correlates of depressive symptoms among household members
Global Health Action2023-08-095 citations
Prevalence and correlates of internalized stigma among adults with HIV and major depressive disorder in rural Malawi
AIDS Care2023-03-313 citations
Stepped care for depression at integrated chronic care centers (IC3) in Malawi: study protocol for a stepped-wedge cluster randomized controlled trial.
2021-09-165 citations