Pralatrexate Injection
Sponsors
Acrotech Biopharma Inc., Spectrum Pharmaceuticals, Inc, Mundipharma K.K.
Conditions
Advanced Solid TumorsB-cell LymphomaBladder CancerBladder NeoplasmBreast CancerBreast TumorsCancer of the BreastCarcinoma, Transitional Cell
Phase 1
Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies
CompletedNCT00481871
Start: 2007-05-31End: 2011-08-31Updated: 2020-01-07
Pralatrexate and Bexarotene in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma
CompletedNCT01134341
Start: 2010-03-31End: 2015-08-31Updated: 2019-12-18
Phase I/II Clinical Study of Pralatrexate in Japanese Patients With Relapsed or Refractory Peripheral T-cell Lymphoma
CompletedNCT02013362
Start: 2014-03-31End: 2017-09-30Updated: 2017-11-09
A Dose-Finding Study of Folotyn® (Pralatrexate Injection) Plus CHOP With Peripheral T-Cell Lymphoma (PTCL)
CompletedNCT02594267
Start: 2015-11-10End: 2020-10-08Updated: 2021-07-27
Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment
RecruitingNCT07036133
Start: 2022-12-28End: 2027-09-01Target: 24Updated: 2026-02-11
Phase 2
Study of Pralatrexate With Vitamin B12 and Folic Acid in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma
CompletedNCT00364923
Start: 2006-08-31End: 2009-02-24Updated: 2019-12-19
Study of Pralatrexate to Treat Advanced or Metastatic Relapsed Transitional Cell Carcinoma of the Urinary Bladder
CompletedNCT00722553
Start: 2008-07-31End: 2011-09-30Updated: 2019-12-17
Study of Pralatrexate in Female Patients With Previously-treated Breast Cancer
CompletedNCT01118624
Start: 2010-03-31End: 2012-07-31Updated: 2020-01-07
Phase 3
Pralatrexate vs Observation Following CHOP-based Chemotherapy in Undiagnosed Peripheral T-cell Lymphoma Patients
TerminatedNCT01420679
Start: 2011-08-31End: 2017-12-31Updated: 2021-11-19
To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCL
RecruitingNCT06072131
Start: 2023-10-04End: 2030-11-01Target: 504Updated: 2026-07-22