Polypill

DRUG11 trials

Sponsors

Tehran University of Medical Sciences, Imperial College London, Isfahan University of Medical Sciences, University of Texas Southwestern Medical Center, University Medical Center Utrecht

Conditions

Acute Coronary SyndromeAcute Myocardial InfarctionCardiovascular DiseaseCardiovascular DiseasesCirculatory System Pregnancy and Childbirth Hypertensive disorders in pregnancy, pregnancy-induced hypertension, preeclampsiaCoronary Artery DiseaseHeart DiseaseHeart Failure

Phase 1

Polypill for Prevention of Cardiomyopathy

RecruitingNCT06143566

University of Texas Southwestern Medical CenterHigh Blood Pressure, Type 2 Diabetes

Start: 2024-03-11End: 2027-12-01Target: 200Updated: 2025-06-17

Phase 2

Phase II Study of Heart Polypill Safety and Efficacy in Primary Prevention of Cardiovascular Disease

CompletedNCT00603590

Tehran University of Medical SciencesCardiovascular Disease, Heart Disease, Hyperlipidemia +1

Start: 2006-11-30End: 2008-07-31Updated: 2009-10-02

Polypill Strategy for Heart Failure With Reduced Ejection Fraction

CompletedNCT04633005

University of Texas Southwestern Medical CenterHeart Failure

Start: 2021-11-15End: 2025-10-31Updated: 2025-11-21

Polypill in Acute Coronary Syndrome

CompletedNCT05514938

University of Texas Southwestern Medical CenterAcute Coronary Syndrome, Coronary Artery Disease, Lipid Disorder

Start: 2022-11-30End: 2025-06-05Updated: 2025-06-11

A Polypill for Acute Coronary Syndrome

RecruitingNCT07032389

University of Texas Southwestern Medical CenterAcute Coronary Syndrome

Start: 2025-12-05End: 2029-08-01Target: 1000Updated: 2026-01-20

Phase 3

UMPIRE - Use of a Multidrug Pill In Reducing Cardiovascular Events

CompletedNCT01057537

Imperial College LondonCardiovascular Diseases

Start: 2010-06-30End: 2012-09-30Updated: 2012-11-27

Prevention of Cardiovascular Disease Using a Single PolyPill in an Urban Population - Focus on Liver-Related Variables.

CompletedNCT01245608

Tehran University of Medical SciencesCardiovascular Diseases

Start: 2011-10-31End: 2018-09-30Updated: 2019-02-15

Prevention of Cardiovascular Disease in Middle-aged and Elderly Iranians Using a Single PolyPill

CompletedNCT01271985

Tehran University of Medical SciencesCardiovascular Diseases

Start: 2011-02-28End: 2019-01-31Updated: 2019-01-22

Prevention of Cardiovascular Disease With Polypill Among Pars Cohort Participants

Tehran University of Medical SciencesCardiovascular Diseases

Start: 2015-12-20End: 2022-03-20Updated: 2021-02-10

A Polypill for Secondary Prevention of Ischemic Heart Disease

Isfahan University of Medical SciencesAcute Myocardial Infarction, Non-ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction

Start: 2019-05-20End: 2024-08-31Target: 1200Updated: 2020-10-14

Unknown Phase

Prospects for the Prevention of Pregnancy-induced Hypertension and Preeclampsia Trial

Active, not recruitingPACTR201311000700893

University Medical Center UtrechtCirculatory System Pregnancy and Childbirth Hypertensive disorders in pregnancy, pregnancy-induced hypertension, preeclampsia

Start: 2015-10-01Target: 440Updated: 2026-01-27

Related Papers

Patient Perspectives on a Polypill Strategy for Heart Failure with Reduced Ejection Fraction: A Convergent-Parallel Mixed Methods Study Embedded in a Randomized Clinical Trial.

2025-11-101 citations

Rationale, Design, and Baseline Characteristics of the Polypill for Heart Failure with Reduced Ejection Fraction (POLY-HF) Trial.

2025-10-311 citations

Delivering guideline-directed medical therapy for heart failure with reduced ejection fraction as an over-encapsulated polypill: rationale and protocol for the COMBO-HF-X pilot crossover randomised clinical trial

BMJ Open2025-03-013 citations

Effectiveness of polypill for primary and secondary prevention of cardiovascular disease: a pragmatic cluster-randomised controlled trial (PolyPars)

Heart2024-03-149 citations

Fixed dose combination therapies in primary cardiovascular disease prevention in different groups: an individual participant meta-analysis.

2023-08-243 citations

Polypill for prevention of cardiovascular diseases with focus on non-alcoholic steatohepatitis: the PolyIran-Liver trial

European Heart Journal2021-12-2924 citations

Effectiveness of Polypill for Prevention of Cardiovascular Disease (PolyPars): Protocol of a Randomized Controlled Trial

Archives of Iranian Medicine2020-08-014 citations

Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial.

2019-08-01196 citations

PolyPill for Prevention of Cardiovascular Disease in an Urban Iranian Population with Special Focus on Nonalcoholic Steatohepatitis: A Pragmatic Randomized Controlled Trial within a Cohort (PolyIran - Liver) - Study Protocol.

2015-08-0123 citations

Effects of a Fixed-Dose Combination Strategy on Adherence and Risk Factors in Patients With or at High Risk of CVD

JAMA2013-09-03397 citations