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DRUG5 trials

Sponsors

Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC), Stichting Radboud universitair medisch centrum, AstraZeneca AB, Universitair Ziekenhuis Gent, UZ Leuven

Conditions

Dystonic tremor syndromeInfective EndocarditisLarge B-cell LymphomaPatients undergoing Fludarabine based lymphodepletion prior to CAR-T cell therapySepsisfor hematological malignancy

Phase 3

Beta-Lactam antibiotics initiaL expoSure optimisEd in criticallY ill patients with sEpsis (BuLLSEYE)
RecruitingCTIS2024-512950-13-00
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)Sepsis
Start: 2025-01-03Target: 988Updated: 2026-01-05
A Phase III, Multicentre, Open-Label, Randomised Study Evaluating the Efficacy and Safety of R-mini-CHOP x2 followed by AZD0486 versus R-mini-CHOP x6 in Elderly or Unfit Participants with Newly Diagnosed Large B-cell Lymphoma (SOUNDTRACK-D2)
Not yet recruitingCTIS2025-522029-37-00
AstraZeneca ABLarge B-cell Lymphoma
Target: 14Updated: 2026-01-30

Phase 4

Factors Determining the Efficacy of Botulinum Toxin for Arm Tremor in Dystonia: An Exploratory Study
RecruitingCTIS2024-515970-28-00
Stichting Radboud universitair medisch centrumDystonic tremor syndrome
Start: 2024-12-20Target: 60Updated: 2024-11-11
Rapid Oral Switch in Infectious Endocarditis, the ROSIE trial
Not yet recruitingCTIS2025-524484-20-00
UZ LeuvenInfective Endocarditis
Target: 152Updated: 2026-02-06
Fludarabine exposure in patients undergoing Fludarabine based lymphodepletion prior to CAR-T cell therapy
Not yet recruitingCTIS2025-524278-40-00
Universitair Ziekenhuis Gentfor hematological malignancy, Patients undergoing Fludarabine based lymphodepletion prior to CAR-T cell therapy
Target: 75Updated: 2026-03-23

Related Papers

Standard versus double dosing of beta-lactam antibiotics in critically ill patients with sepsis: The BULLSEYE study protocol for a multicenter randomized controlled trial
BMC Infectious Diseases2025-03-212 citations