Placebo to tocilizumab

DRUG3 trials

Sponsors

Hoffmann-La Roche

Conditions

Rheumatoid Arthritis

Phase 3

A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid Arthritis

CompletedNCT01007435

Hoffmann-La RocheRheumatoid Arthritis

Start: 2009-10-31End: 2014-01-28Updated: 2017-07-26

Phase 4

A Study of Tocilizumab (RoActemra/Actemra) Versus Adalimumab in Patients With Rheumatoid Arthritis

CompletedNCT01119859

Hoffmann-La RocheRheumatoid Arthritis

Start: 2010-05-31End: 2012-01-31Updated: 2013-02-11

A Study of RoActemra/Actemra (Tocilizumab) Versus Adalimumab in Combination With Methotrexate (MTX) in Patients With Moderate to Severe Active Rheumatoid Arthritis And an Inadequate Response to Treatment With Only One Tumor Necrosis Factor (TNF)-Inhibitor

TerminatedNCT01283971

Hoffmann-La RocheRheumatoid Arthritis

Start: 2011-05-31End: 2012-08-31Updated: 2014-02-10

Related Papers

Impact of tocilizumab monotherapy on patient-reported outcomes in patients with rheumatoid arthritis from two randomised controlled trials

RMD Open2017-09-0128 citations

Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial.

2017-04-0760 citations

Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial

Annals of the Rheumatic Diseases2016-11-18306 citations

Comparison of lipid and lipid-associated cardiovascular risk marker changes after treatment with tocilizumab or adalimumab in patients with rheumatoid arthritis.

2015-11-27115 citations

Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial

Annals of the Rheumatic Diseases2015-10-29193 citations

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics.

2014-04-30271 citations

Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial.

2013-03-18469 citations