Placebo (matched to NNC0487-0111)

DRUG8 trials

Sponsors

Novo Nordisk A/S

Conditions

Diabetes MellitusDiabetes Mellitus, Type 2ObesityObstructive Sleep ApnoeaOsteoarthritis, KneeOverweight

Phase 1

A Research Study Looking at How NNC0487-0111 Affects Food Intake, Appetite and Metabolism After Meals in People With Obesity

RecruitingNCT07508020

Novo Nordisk A/SObesity

Start: 2026-03-30End: 2028-01-22Target: 120Updated: 2026-04-27

Phase 3

AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

RecruitingNCT07339423

Novo Nordisk A/SObesity

Start: 2026-02-24End: 2029-08-21Target: 1150Updated: 2026-05-13

AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

Not yet recruitingNCT07400107

Novo Nordisk A/SDiabetes Mellitus, Type 2, Obesity, Overweight

Start: 2026-05-20End: 2029-01-26Target: 1000Updated: 2026-03-12

AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

RecruitingNCT07503210

Novo Nordisk A/SObesity

Start: 2026-04-21End: 2028-07-04Target: 600Updated: 2026-05-19

AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

RecruitingNCT07509307

Novo Nordisk A/SObesity, Osteoarthritis, Knee, Overweight

Start: 2026-04-20End: 2028-08-14Target: 400Updated: 2026-05-15

AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

RecruitingNCT07533175

Novo Nordisk A/SDiabetes Mellitus, Obesity, Overweight

Start: 2026-04-13End: 2028-08-07Target: 630Updated: 2026-05-19

AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

RecruitingNCT07571109

Novo Nordisk A/SObesity, Obstructive Sleep Apnoea, Overweight

Start: 2026-05-05End: 2028-08-21Target: 300Updated: 2026-05-22

AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

RecruitingNCT07571005

Novo Nordisk A/SObesity, Obstructive Sleep Apnoea, Overweight

Start: 2026-05-05End: 2028-10-04Target: 300Updated: 2026-05-22