PIPERACILLIN

DRUG9 trials

Conditions

Bacterial PneumoniaCritical Patients admitted to the ICUFebrile neutropeniaHealthy SubjectsHematopoietic Stem Cell TransplantationIntensive CareNeutropeniaSerious infections in critically ill patients treated with antibiotics

Phase 1

Study Evaluating BLI-489 and Piperacillin in Healthy Subjects

CompletedNCT00894439

Wyeth is now a wholly owned subsidiary of PfizerHealthy Subjects

Start: 2009-05-31End: 2009-07-31Updated: 2009-07-17

Phase 3

Imipenem/Relebactam/Cilastatin Versus Piperacillin/Tazobactam for Treatment of Participants With Bacterial Pneumonia (MK-7655A-014)

CompletedNCT02493764

Merck Sharp & Dohme LLCBacterial Pneumonia

Start: 2015-11-24End: 2019-04-03Updated: 2020-04-16

A RANDOMIZED PROSPECTIVE CLINICAL TRIAL TO ASSESS PROCALCITONIN-GUIDANCE AND MOLECULAR-GUIDED DIAGNOSIS AS MAINSTAY FOR THERAPY OF SEVERE INFECTIONS (The MODIFY trial)

Active, not recruitingCTIS2022-502962-26-00

Hellenic Institute For The Study Of SepsisSevere infections

Start: 2023-09-14Target: 190Updated: 2025-11-03

COTRIVAP - Efficacy of cotrimoxazole as a de-escalation treatment of Ventilator-Associated Pneumonia in intensive care unit. Multicentric non-inferiority randomised controlled trial

CompletedCTIS2023-505108-52-00

Assistance Publique Hopitaux De ParisIntensive Care, Ventilator-associated Pneumonia

Start: 2023-12-20End: 2025-09-19Target: 628Updated: 2025-04-23

BICCS - Beta-lactam Intermittent versus Continuous infusion and Combination antibiotic therapy in Sepsis

Not yet recruitingCTIS2024-516849-39-01

Assistance Publique Hopitaux De Parisantibiotic therapy in Sepsis

Target: 600Updated: 2025-12-02

Phase 4

Clinical impact of pharmacokinetic monitoring of antibiotics in critically ill patients

Not yet recruitingCTIS2023-504480-17-00

Fundacio Institut De Recerca De L Hospital De La Santa Creu I Sant PauCritical Patients admitted to the ICU

Target: 384Updated: 2024-03-11

SAFE study: Stopping Antibiotics after 3 days for the treatment of FEbrile Neutropenia in Haematology patients, a randomized open-label non-inferiority trial

RecruitingCTIS2022-500389-84-00

UZ LeuvenFebrile neutropenia

Start: 2024-02-16Target: 410Updated: 2025-11-13

Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether contemporary antibiotic dosing for critically ill patients achieves therapeutic exposures.

Not yet recruitingCTIS2024-516232-10-00

Centre Hospitalier Universitaire De NimesSerious infections in critically ill patients treated with antibiotics

Target: 200Updated: 2025-10-17

Unknown Phase

Prophylactic Piperacillin/Tazobactam in Hematopoietic Stem Cell Transplantation

NCT01714557

Chinese PLA General HospitalHematopoietic Stem Cell Transplantation, Neutropenia

Start: 2012-09-30End: 2014-11-30Target: 150Updated: 2012-10-26

2026-01-26

Participant- and Disease-Related Factors as Independent Predictors of Treatment Outcomes in the RESTORE-IMI 2 Clinical Trial: A Multivariable Regression Analysis

Open Forum Infectious Diseases2023-05-043 citations

Population pharmacokinetic/pharmacodynamic assessment of imipenem/cilastatin/relebactam in patients with hospital‐acquired/ventilator‐associated bacterial pneumonia

Clinical and Translational Science2021-10-2730 citations

A Randomized, Double-blind, Multicenter Trial Comparing Efficacy and Safety of Imipenem/Cilastatin/Relebactam Versus Piperacillin/Tazobactam in Adults With Hospital-acquired or Ventilator-associated Bacterial Pneumonia (RESTORE-IMI 2 Study)

Clinical Infectious Diseases2020-07-06211 citations