PA-824
Sponsors
Global Alliance for TB Drug Development, National Institute of Allergy and Infectious Diseases (NIAID), Johns Hopkins University
Conditions
Pulmonary TuberculosisRenal ImpairmentTuberculosisTuberculosis, Pulmonary, Drug SensitiveTuberculosis, Pulmonary, Multi Drug-resistant
Phase 1
Evaluating the Safety and Drug Interaction of PA-824, an Investigational Tuberculosis Medication, Together With Efavirenz, Ritonavir-Boosted Lopinavir, or Rifampin
CompletedNCT01571414
Start: 2012-05-31End: 2013-05-31Updated: 2021-11-05
Effect of PA-824 and of PA-824 Plus Moxifloxacin on the QTc Interval in Healthy Volunteers
CompletedNCT01674218
Start: 2012-09-30End: 2012-12-31Updated: 2014-11-14
Evaluation of the Pharmacokinetic Interaction Between PA-824 and Midazolam
CompletedNCT01768273
Start: 2009-12-31End: 2010-04-30Updated: 2019-09-12
Pretomanid in Adults With Hepatic Impairment
TerminatedNCT02422524
Start: 2018-03-29End: 2023-11-17Updated: 2025-06-10
A Study of the Safety, Tolerability, and Absorption, Metabolism, and Excretion of PA-824 in Healthy Adult Male Subjects.
CompletedNCT03202693
Start: 2006-03-31End: 2006-05-31Updated: 2018-08-02
Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared to Participants With Normal Renal Function
CompletedNCT03896750
Start: 2024-04-17End: 2024-10-28Updated: 2025-11-25
Phase 2
PA-824-CL-007: Phase IIa Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis
CompletedNCT00567840
Start: 2007-08-31End: 2007-12-31Updated: 2017-05-15
Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis (CL-010)
CompletedNCT00944021
Start: 2009-08-31End: 2010-05-31Updated: 2019-09-20
Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With(J-M-Pa-Z) (NC-001)
CompletedNCT01215851
Start: 2010-10-31End: 2011-08-31Updated: 2017-02-28
A Phase 2 to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide in Adult Subjects With Drug-Sensitive or Multi Drug-Resistant Pulmonary Tuberculosis.
CompletedNCT02193776
Start: 2014-10-23End: 2018-02-07Updated: 2019-07-26
Assessing PA-824 for Tuberculosis (the APT Trial)
CompletedNCT02256696
Start: 2015-04-29End: 2022-05-01Updated: 2023-07-18