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Oliceridine

DRUG16 trials

Sponsors

Trevena Inc., The Cleveland Clinic, University of Tennessee, Peking University First Hospital, Yuwei Qiu

Conditions

Acute PainAdverse Drug EventAnalgesiaBurnsCerebellopontine Angle TumorChronic Postsurgical PainGastrointestinal EndoscopyGeneral Anesthetic

Phase 3

Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy
CompletedNCT02815709
Trevena Inc.Acute Pain
Start: 2016-05-31End: 2017-01-31Updated: 2020-09-25
Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty
CompletedNCT02820324
Trevena Inc.Acute Pain
Start: 2016-05-31End: 2017-01-31Updated: 2020-10-23

Phase 4

Intravenous Oliceridine and Opioid-related Complications
CompletedNCT04979247
The Cleveland ClinicMajor Surgery
Start: 2021-09-15End: 2024-01-10Updated: 2025-10-02
Oliceridine in Patients With Acute Burn Injuries
CompletedNCT05465226
University of TennesseeAcute Pain, Adverse Drug Event, Burns +2
Start: 2023-04-01End: 2023-10-24Updated: 2023-10-26
Effect of Oliceridine Analgesia on Postoperative Nause and Vomiting
RecruitingNCT06411665
Peking University First HospitalPostoperative Nausea and Vomiting
Start: 2024-07-02End: 2026-12-31Target: 252Updated: 2024-10-08
To Evaluate the Efficacy and Safety of Tegileridine and Oliceridine Injections in the Treatment of Postoperative Pain
CompletedNCT06458400
Yuwei QiuAnalgesia
Start: 2024-07-03End: 2024-10-06Updated: 2025-01-01
The Effect of Oliceridine Patient-Controlled Intravenous Analgesia on Postoperative Chronic Pain After Video-Assisted Thoracoscopic Lobectomy
Not yet recruitingNCT07018375
Tianjin Medical University General HospitalChronic Postsurgical Pain
Start: 2026-01-06End: 2027-04-30Target: 320Updated: 2026-01-06
Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery
RecruitingNCT07026162
YanYing XiaoGynecologic Surgical Procedures, Laparoscopy, Postoperative Nausea and Vomiting (PONV)
Start: 2025-07-21End: 2026-01-31Target: 96Updated: 2025-07-29
Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients
CompletedNCT07306702
Shenyang Sixth People's HospitalPostoperative Pain Management
Start: 2023-07-01End: 2024-06-02Updated: 2025-12-29

Unknown Phase

Clinical Study of G Protein Biased Μ - Opioid Receptor Agonist Oliceridine for Optimizing Postoperative Analgesia Under General Anesthesia
Not yet recruitingNCT06668298
Henan Provincial People's HospitalOld Age
Start: 2024-11-30End: 2025-06-30Target: 150Updated: 2024-10-31
Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial
RecruitingNCT06990893
Anqing Municipal HospitalMorphine, Oliceridine, Safety +2
Start: 2024-11-11End: 2026-10-01Target: 90Updated: 2025-05-25
Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy
Not yet recruitingNCT07097038
Henan Provincial People's HospitalVitrectomy
Start: 2025-07-31End: 2026-07-31Target: 120Updated: 2025-07-31
Efficacy of Oxalidine and Sufentanil in Strabismus Correction
Not yet recruitingNCT07112157
Henan Provincial People's HospitalStrabismus Surgery
Start: 2025-08-31End: 2026-08-31Target: 290Updated: 2025-08-08
Respiratory Safety of Oliceridine During Sedated Gastrointestinal Endoscopy
CompletedNCT07187765
Shiyou WeiGastrointestinal Endoscopy, Hypoxemia During Surgery
Start: 2025-09-22End: 2025-12-01Updated: 2026-01-05
Effects and Safety of Oliceridine in Anesthesia Induction:A Randomised Controlled Trial
CompletedNCT07372209
Tangshan Maternal and Child Health HospitalGeneral Anesthetic, Gynecological Laparoscopic Surgery, Intubation
Start: 2025-10-01End: 2025-12-31Updated: 2026-01-28
Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery
Not yet recruitingNCT07479446
Xuanwu Hospital, BeijingCerebellopontine Angle Tumor, Microvascular Decompression Surgery, PONV +1
Start: 2026-03-01End: 2027-09-30Target: 174Updated: 2026-03-18

Related Papers

Oliceridine for postoperative pain and opioid-related complications: The intravenous oliceridine and opioid-related complications (VOLITION) prospective cohort study.
2025-05-292 citations
APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the μ-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty.
2019-06-24116 citations
APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy.
2019-03-11103 citations