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Olezarsen

DRUG11 trials

Sponsors

Ionis Pharmaceuticals, Inc.

Conditions

AtherosclerosisAtherosclerotic Cardiovascular DiseaseCardiovascular DiseasesFamilial Chylomicronemia SyndromeHealthy ParticipantsHypertriglyceridemiaSevere Hypertriglyceridemia

Phase 1

Phase 2

Phase 3

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) Administered to Patients With Familial Chylomicronemia Syndrome (FCS)
CompletedNCT04568434
Ionis Pharmaceuticals, Inc.Familial Chylomicronemia Syndrome
Start: 2020-11-18End: 2023-10-17Updated: 2025-03-06
A Study of Olezarsen (ISIS 678354) Administered to Participants With Severe Hypertriglyceridemia
CompletedNCT05079919
Ionis Pharmaceuticals, Inc.Severe Hypertriglyceridemia
Start: 2021-10-25End: 2025-07-08Updated: 2026-02-10
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS)
Active, not recruitingNCT05130450
Ionis Pharmaceuticals, Inc.Familial Chylomicronemia Syndrome
Start: 2021-11-18End: 2028-02-29Updated: 2025-12-12
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemia Syndrome (FCS) Previously Treated With Volanesorsen
Active, not recruitingNCT05185843
Ionis Pharmaceuticals, Inc.Familial Chylomicronemia Syndrome
Start: 2022-02-25End: 2027-06-30Updated: 2025-12-12
A Study of Olezarsen Administered Subcutaneously to Participants With Severe Hypertriglyceridemia
CompletedNCT05552326
Ionis Pharmaceuticals, Inc.Severe Hypertriglyceridemia
Start: 2022-08-31End: 2025-09-12Updated: 2025-10-22
A Study of Olezarsen (ISIS 678354) in Participants With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease, or With Severe Hypertriglyceridemia
CompletedNCT05610280
Ionis Pharmaceuticals, Inc.Atherosclerosis, Cardiovascular Diseases, Hypertriglyceridemia
Start: 2022-11-21End: 2025-06-09Updated: 2026-02-10
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
Active, not recruitingNCT05681351
Ionis Pharmaceuticals, Inc.Severe Hypertriglyceridemia
Start: 2022-12-13End: 2027-03-31Updated: 2025-12-01
A Study of Olezarsen for the Treatment of Familial Chylomicronemia Syndrome (FCS) in Pediatric Participants
RecruitingNCT07727538
Ionis Pharmaceuticals, Inc.Familial Chylomicronemia Syndrome
Start: 2026-07-31End: 2031-08-01Target: 12Updated: 2026-08-26

Unknown Phase

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