Normal Nicotine Content Cigarettes

DRUG6 trials

Sponsors

Saul Shiffman, Duke University, University of Minnesota, Milton S. Hershey Medical Center, Brown University

Conditions

E-Cig UseNicotine DependenceNicotine Dependence, Cigarettes, UncomplicatedSmokingSmoking, CigaretteTobacco DependenceTobacco Smoking

Phase 1

Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco

CompletedNCT03860077

Brown UniversityNicotine Dependence, Cigarettes, Uncomplicated

Start: 2019-10-10End: 2022-03-23Updated: 2023-12-19

Phase 3

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

CompletedNCT03272685

University of MinnesotaNicotine Dependence, Tobacco Smoking

Start: 2018-06-01End: 2023-01-10Updated: 2024-08-20

Unknown Phase

Very-Low Nicotine Cigarettes and Non-Daily Smokers

CompletedNCT02228824

Saul ShiffmanSmoking

Start: 2015-06-30End: 2017-07-31Updated: 2018-10-31

Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers

CompletedNCT02989038

Duke UniversityNicotine Dependence

Start: 2017-01-31End: 2019-12-17Updated: 2020-03-04

Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes

CompletedNCT03612960

Milton S. Hershey Medical CenterTobacco Dependence

Start: 2020-02-20End: 2023-06-23Updated: 2024-08-20

Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2

CompletedNCT05473585

Duke UniversityE-Cig Use, Nicotine Dependence, Smoking +1

Start: 2022-10-12End: 2023-05-09Updated: 2023-07-19

Related Papers

Titration of nicotine intake in smokers switching to reduced nicotine content cigarettes with access to alternative nicotine systems: Secondary analysis of a randomized clinical trial.

2026-03-19

Secondary analysis of a randomized clinical trial of very low nicotine cigarettes: Outcomes across social and demographic groups.

2025-07-21

Reduced nicotine in cigarettes in a marketplace with alternative nicotine systems: randomized clinical trial.

2024-06-0318 citations

Nondaily Smokers’ Changes in Cigarette Consumption With Very Low-Nicotine-Content Cigarettes

JAMA Psychiatry2018-06-1446 citations