NNC0487-0111
Sponsors
Novo Nordisk A/S
Conditions
Diabetes Mellitus, Type 2Knee Osteoarthritis (OA)ObesityOsteoarthritis, KneeOverweightType 2 Diabetes
Phase 1
A Research Study of How a New Medicine Called Amycretin, Given as Tablets, Works in Japanese Men With Obesity
CompletedNCT06049329
Start: 2023-09-14End: 2023-12-15Updated: 2025-03-05
A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function
CompletedNCT06559527
Start: 2024-08-20End: 2025-03-05Updated: 2025-03-30
A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants After 10 Days of Oral Dosing
CompletedNCT06820476
Start: 2025-02-09End: 2025-05-14Updated: 2025-08-20
A Research Study Looking at How NNC0487-0111 Affects Food Intake, Appetite and Metabolism After Meals in People With Obesity
Not yet recruitingNCT07508020
Start: 2026-03-30End: 2028-01-22Target: 120Updated: 2026-04-02
Phase 2
A Research Study to See How a New Medicine (NNC0487-0111) Works in People With Overweight or Obesity When Injected Under the Skin
CompletedNCT06064006
Start: 2023-09-15End: 2024-11-27Updated: 2025-11-19
Safety and efficacy of once-weekly subcutaneous and once-daily oral NNC0487-0111 in participants with type 2 diabetes – a dose finding study
CompletedCTIS2023-509412-28-00
Start: 2024-07-26End: 2025-10-08Target: 339Updated: 2025-11-24
Phase 3
AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
RecruitingNCT07339423
Start: 2026-02-24End: 2029-08-21Target: 1150Updated: 2026-03-04
AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
Not yet recruitingNCT07400107
Start: 2026-05-20End: 2029-01-26Target: 1000Updated: 2026-03-12
A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Not yet recruitingNCT07481630
Start: 2026-04-13End: 2028-07-17Target: 400Updated: 2026-03-19
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
Not yet recruitingNCT07503210
Start: 2026-04-21End: 2028-07-04Target: 600Updated: 2026-03-31
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Not yet recruitingNCT07509307
Start: 2026-04-13End: 2028-07-17Target: 400Updated: 2026-04-03