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NNC0487-0111

DRUG18 trials

Sponsors

Novo Nordisk A/S

Conditions

Diabetes MellitusDiabetes Mellitus, Type 2Heart FailureKnee Osteoarthritis (OA)ObesityObstructive Sleep ApnoeaOsteoarthritis, KneeOverweight

Phase 1

A Research Study of How a New Medicine Called Amycretin, Given as Tablets, Works in Japanese Men With Obesity
CompletedNCT06049329
Novo Nordisk A/SObesity
Start: 2023-09-14End: 2023-12-15Updated: 2025-03-05
A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function
CompletedNCT06559527
Novo Nordisk A/SDiabetes Mellitus, Type 2, Obesity, Overweight
Start: 2024-08-20End: 2025-03-05Updated: 2025-03-30
A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants After 10 Days of Oral Dosing
CompletedNCT06820476
Novo Nordisk A/SObesity, Overweight
Start: 2025-02-09End: 2025-05-14Updated: 2026-08-25
A Research Study Looking at How NNC0487-0111 Affects Food Intake, Appetite and Metabolism After Meals in People With Obesity
RecruitingNCT07508020
Novo Nordisk A/SObesity
Start: 2026-03-30End: 2028-01-22Target: 120Updated: 2026-04-27
Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes
RecruitingNCT07535307
Novo Nordisk A/SDiabetes Mellitus
Start: 2026-04-10End: 2027-12-06Target: 80Updated: 2026-04-24
A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in People With Reduced Liver Function and Normal Liver Function
Not yet recruitingNCT07587710
Novo Nordisk A/SObesity, Overweight
Start: 2026-05-13End: 2027-12-01Target: 35Updated: 2026-05-14
A Research Study to See How NNC0487-0111 Affects the Body's Energy Use After a Weight Loss in Adults Living With Obesity, Compared to a Low-calorie Diet or Placebo
RecruitingNCT07757087
Novo Nordisk A/SObesity, Overweight
Start: 2026-08-03End: 2028-09-18Target: 120Updated: 2026-09-02

Phase 2

Phase 3

AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
RecruitingNCT07339423
Novo Nordisk A/SObesity
Start: 2026-02-24End: 2029-08-21Target: 1150Updated: 2026-07-09
AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
Not yet recruitingNCT07400107
Novo Nordisk A/SDiabetes Mellitus, Type 2, Obesity, Overweight
Start: 2026-05-20End: 2029-01-26Target: 1000Updated: 2026-03-12
A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
RecruitingNCT07481630
Novo Nordisk A/SKnee Osteoarthritis (OA), Obesity
Start: 2026-04-13End: 2028-08-14Target: 400Updated: 2026-07-09
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
RecruitingNCT07503210
Novo Nordisk A/SObesity
Start: 2026-04-21End: 2028-07-04Target: 600Updated: 2026-08-27
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
RecruitingNCT07509307
Novo Nordisk A/SObesity, Osteoarthritis, Knee, Overweight
Start: 2026-04-20End: 2028-08-14Target: 400Updated: 2026-08-17
AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
RecruitingNCT07533175
Novo Nordisk A/SDiabetes Mellitus, Obesity, Overweight
Start: 2026-04-13End: 2028-08-07Target: 630Updated: 2026-09-04
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
RecruitingNCT07567001
Novo Nordisk A/SHeart Failure, Obesity
Start: 2026-05-11End: 2029-08-15Target: 5610Updated: 2026-08-18
AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
RecruitingNCT07571005
Novo Nordisk A/SObesity, Obstructive Sleep Apnoea, Overweight
Start: 2026-05-05End: 2028-10-04Target: 300Updated: 2026-07-13
AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
RecruitingNCT07571109
Novo Nordisk A/SObesity, Obstructive Sleep Apnoea, Overweight
Start: 2026-05-05End: 2028-08-21Target: 300Updated: 2026-09-09

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