Nicotinamide Riboside (NR)

DIETARY_SUPPLEMENT20 trials

Conditions

AgingAllogeneic Hematopoietic Cell TransplantationAlzheimer Disease (AD)AtherosclerosisCancerChronic Kidney DiseaseCoronary Artery DiseaseDiabetes

Early Phase 1

Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation

RecruitingNCT04332341

Case Comprehensive Cancer CenterAllogeneic Hematopoietic Cell Transplantation

Start: 2020-05-19End: 2026-09-01Target: 20Updated: 2026-08-06

Phase 1

Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome

CompletedNCT03789175

National Heart, Lung, and Blood Institute (NHLBI)Cancer, Muscle Weakness, Skin Fibroblasts

Start: 2019-03-25End: 2019-11-01Updated: 2020-12-08

Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The NEET Trial)

CompletedNCT04112043

University of FloridaHypertension

Start: 2020-07-28End: 2023-05-26Updated: 2024-06-06

NAD-brain: a Pharmacokinetic Study of NAD Replenishment Therapy

CompletedNCT05698771

Haukeland University HospitalHealthy

Start: 2022-09-17End: 2024-03-04Updated: 2025-01-17

Nicotinamide Riboside (NR) to Treat Moyamoya-like Cerebrovascular Disease in Smooth Muscle Dysfunction Syndrome (SMDS)

RecruitingNCT06280482

The University of Texas Health Science Center, HoustonSmooth Muscle Dysfunction Syndrome (SMDS)

Start: 2024-03-06End: 2027-07-25Target: 15Updated: 2025-09-12

Phase 2

Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants

Not yet recruitingNCT04614714

University of California, DavisInadequate Milk Production, Preterm Birth

Start: 2026-06-01End: 2026-06-30Target: 40Updated: 2026-05-18

Mental Intervention and Nicotinamide Riboside Supplementation in Long Covid

CompletedNCT05703074

University Hospital, AkershusLong COVID

Start: 2023-01-30End: 2025-06-23Updated: 2026-08-25

The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging

RecruitingNCT06208527

Haukeland University HospitalAging, Frail Elderly Syndrome, Frailty +1

Start: 2025-01-31End: 2030-12-31Target: 100Updated: 2025-01-20

The NAD-HD Study: A Study to Investigate Efficacy and Safety of Nicotinamide Riboside Compared With Placebo in Huntington's Disease

RecruitingNCT06853743

Oslo University HospitalHuntington Disease

Start: 2025-03-18End: 2029-03-31Target: 120Updated: 2025-03-19

NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals

RecruitingNCT06971224

Haukeland University HospitalSleep

Start: 2025-10-13End: 2026-06-01Target: 16Updated: 2025-09-15

Nicotinamide Riboside Supplementation in Chronic Kidney Disease

Not yet recruitingNCT07693543

University of California, San DiegoChronic Kidney Disease

Start: 2026-10-01End: 2028-09-30Target: 30Updated: 2026-07-15

N-AD: Orally Administered Nicotinamide Riboside Over Two Years as a Potential Disease Modifying Treatment for Alzheimer's Disease

RecruitingNCT07741071

Haukeland University HospitalAlzheimer Disease (AD)

Start: 2026-08-26End: 2030-04-30Target: 270Updated: 2026-08-20

Phase 3

The NICE-PAD II Trial

Not yet recruitingNCT07782671

Northwestern UniversityPeripheral Artery Disease (PAD)

Start: 2026-12-01End: 2031-07-01Target: 250Updated: 2026-08-24

Unknown Phase

Study to Evaluate the Effect of Nicotinamide Riboside on Immunity

CompletedNCT02812238

National Heart, Lung, and Blood Institute (NHLBI)Atherosclerosis, Coronary Artery Disease, Diabetes

Start: 2016-06-23End: 2018-08-28Updated: 2019-09-17

Effect of Oral NAD+ Precursors Administration on Blood NAD+ Concentration in Healthy Adults

CompletedNCT05517122

Société des Produits Nestlé (SPN)Healthy

Start: 2022-07-12End: 2022-11-24Updated: 2025-04-24

Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity

RecruitingNCT06425042

Finis Terrae UniversityHealthy Aging, Lifestyle-related Condition, Metabolic Diseases

Start: 2024-03-01End: 2026-03-31Target: 28Updated: 2025-07-11

Acute Effects of Nicotinamide Riboside on Polysomnography-Measured Sleep Structure in Healthy Adults

Not yet recruitingNCT07284225

Eye & ENT Hospital of Fudan UniversityHealthy Volunteers

Start: 2025-12-20End: 2026-12-30Target: 20Updated: 2025-12-16

Effects of NR Supplementation on Metabolic Flexibility in Zone 2 Training

RecruitingNCT07344636

ZHANG JiaqiHealth Adult Subjects

Start: 2026-01-06End: 2027-07-01Target: 16Updated: 2026-03-18

Mechanistic Study of Nicotinamide Riboside on NAD+ Biology in Individuals With Combined Pulmonary Hypertension

RecruitingNCT07563322

Vanderbilt University Medical CenterPulmonary Hypertension

Start: 2026-04-09End: 2027-07-30Target: 10Updated: 2026-05-04

NAD Supplementation in Parkinson's Disease

Enrolling by invitationNCT07703137

University of OklahomaParkinson's Disease

Start: 2026-08-10End: 2027-07-01Target: 40Updated: 2026-08-12

2026-05-01

The differential impact of three different NAD<sup>+</sup> boosters on circulatory NAD and microbial metabolism in humans.

2026-01-15

A pilot study of nicotinamide riboside supplementation in allogeneic bone marrow transplantation

Blood2025-11-03

Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer’s disease

Alzheimer s Research & Therapy2025-03-117 citations

Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes

Journal of Clinical Investigation2022-01-1360 citations