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Neostigmine + Atropine

DRUG6 trials

Sponsors

Merck Sharp & Dohme LLC, China Medical University Hospital, Universitas Padjadjaran, Ain Shams University, Xijing Hospital

Conditions

Colorectal SurgeryEmergence AgitationExtubation ReadinessGeneral Anesthesia Using Endotracheal IntubationNasal SurgeryNeostigmineNeuromuscular BlockadeNeuromuscular Blocking Agents

Phase 1

Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade
RecruitingNCT06794450
Universitas PadjadjaranNeuromuscular Blocking Agents, Recovery Time, Reversal of Neuromuscular Blockade
Start: 2024-11-05End: 2025-02-28Target: 60Updated: 2025-01-28

Phase 3

Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery
Not yet recruitingNCT07271875
Xijing HospitalColorectal Surgery, Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus
Start: 2026-01-01End: 2027-12-31Target: 560Updated: 2025-12-09

Phase 4

Efficacy, Safety, and Pharmacokinetics of Sugammadex for Reversal of Neuromuscular Blockade (NMB) in Pediatric Participants (MK-8616-089)
CompletedNCT03351608
Merck Sharp & Dohme LLCNeuromuscular Blockade
Start: 2018-02-12End: 2020-01-28Updated: 2021-02-05
Efficacy, Safety, and Pharmacokinetics of Sugammadex (MK-8616) for Reversal of Neuromuscular Blockade in Pediatric Participants Aged Birth to <2 Years (MK-8616-169)
CompletedNCT03909165
Merck Sharp & Dohme LLCNeuromuscular Blockade
Start: 2019-07-23End: 2023-09-21Updated: 2025-07-25

Unknown Phase

Sugammadex and Time to Extubation in Ophthalmic Surgery
CompletedNCT06632067
China Medical University HospitalExtubation Readiness, General Anesthesia Using Endotracheal Intubation, Neostigmine +2
Start: 2023-08-01End: 2023-08-31Updated: 2024-10-08
Emergence Agitation
Active, not recruitingNCT07253428
Ain Shams UniversityEmergence Agitation, Nasal Surgery
Start: 2025-10-30End: 2026-01-31Target: 486Updated: 2025-11-28

Related Papers

Sugammadex for Reversal of Neuromuscular Blockade in Neonates and Infants Less than 2 Years Old: Results from a Phase IV Randomized Clinical Trial
Anesthesiology2025-05-055 citations
Sugammadex for reversal of neuromuscular blockade in pediatric patients: Results from a phase IV randomized study
Pediatric Anesthesia2021-12-0822 citations