Neoadjuvant radiation

RADIATION2 trials

Sponsors

University Hospital Schleswig-Holstein, John Rieth

Conditions

Adenocarcinoma of the Esophagogastric JunctionEsophageal Adenocarcinoma (UICC TNM7)Sarcoma,Soft TissueSoft Tissue Sarcoma

Phase 2

Neoadjuvant Intralesional Injection of Talimogene Laherparepvec

Active, not recruitingNCT06660810

John RiethSarcoma,Soft Tissue, Soft Tissue Sarcoma

Start: 2025-03-03End: 2031-02-24Updated: 2026-07-17

Phase 3

Perioperative Chemotherapy Compared To Neoadjuvant Chemoradiation in Patients With Adenocarcinoma of the Esophagus

Active, not recruitingNCT02509286

University Hospital Schleswig-HolsteinAdenocarcinoma of the Esophagogastric Junction, Esophageal Adenocarcinoma (UICC TNM7)

Start: 2016-01-31End: 2024-12-31Updated: 2024-05-08

Related Papers

Patient reported outcomes (PRO) during and after multimodal treatment for resectable esophageal adenocarcinoma in the prospective, randomized, controlled, multicenter phase III ESOPEC trial.

Journal of Clinical Oncology2026-05-27

Abstract P1-12-22: Breast Implant Associated Squamous Cell Carcinoma (BIA-SCC): A Mayo Clinic Multidisciplinary Approach to Treatment

Clinical Cancer Research2025-06-13

Recurrence patterns in the prospective, randomized, controlled, multicenter phase III ESOPEC trial comparing perioperative chemotherapy with preoperative chemoradiotherapy in patients with esophageal adenocarcinoma.

Journal of Clinical Oncology2025-05-282 citations

Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer

New England Journal of Medicine2025-01-22150 citations

Prospective randomized multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (ESOPEC trial).

Journal of Clinical Oncology2024-06-0587 citations

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.

2023-09-18110 citations

Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus minimally invasive esophagectomy for resectable esophageal adenocarcinoma, a randomized controlled trial (ROBOT-2 trial).

2021-09-2667 citations

Oxaliplatin/capecitabine or carboplatin/paclitaxel-based preoperative chemoradiation for resectable oesophageal adenocarcinoma (NeoSCOPE): Long-term results of a randomised controlled trial.

2021-06-2013 citations

RACE-trial: neoadjuvant radiochemotherapy versus chemotherapy for patients with locally advanced, potentially resectable adenocarcinoma of the gastroesophageal junction - a randomized phase III joint study of the AIO, ARO and DGAV.

2020-09-1532 citations

Neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma: a single-Centre, open-label, randomized, controlled, clinical trial (HCHTOG1903).

2020-04-1512 citations

ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286).

2016-07-19260 citations

ESOPEC: A prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy to neoadjuvant chemoradiation in patients with adenocarcinoma of the esophagus (NCT02509286).

Journal of Clinical Oncology2016-05-202 citations