Negative Ion Generator

DEVICE5 trials

Sponsors

VA Office of Research and Development, Yale University, Portland VA Medical Center

Conditions

Chronic PainPost-traumatic Stress DisorderPosttraumatic Stress DisorderSeasonal Affective DisorderTraumatic Brain Injury

Phase 2

A Trial of Negative Ion Generation Versus Light-Emitting Diode Phototherapy for Seasonal Affective Disorder (SAD)

CompletedNCT00809523

Yale UniversitySeasonal Affective Disorder

Start: 2008-12-31End: 2010-04-30Updated: 2013-03-06

Unknown Phase

Bright Light: An Adjunct Treatment for Combat Posttraumatic Stress Disorder (PTSD)

CompletedNCT00701064

VA Office of Research and DevelopmentPosttraumatic Stress Disorder

Start: 2009-01-01End: 2019-09-02Updated: 2019-09-24

Improving Sleep in Veterans With TBI

CompletedNCT03785600

VA Office of Research and DevelopmentTraumatic Brain Injury

Start: 2019-11-01End: 2024-09-30Updated: 2025-09-22

Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans

Active, not recruitingNCT03968874

Portland VA Medical CenterTraumatic Brain Injury

Start: 2019-08-01End: 2025-12-01Target: 300Updated: 2025-11-14

Improving Sleep in Veterans With the Polytrauma Clinical Triad

RecruitingNCT06477796

VA Office of Research and DevelopmentChronic Pain, Post-traumatic Stress Disorder, Traumatic Brain Injury

Start: 2025-05-01End: 2028-09-29Target: 96Updated: 2025-06-27

Related Papers

Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponsored protocol

PLoS ONE2025-01-071 citations

Feasibility and preliminary efficacy for morning bright light therapy to improve sleep and plasma biomarkers in US Veterans with TBI. A prospective, open-label, single-arm trial

PLoS ONE2022-04-1417 citations