MYK-224

DRUG4 trials

Sponsors

Bristol-Myers Squibb

Conditions

Cardiomyopathy, HypertrophicHealthy ParticipantsHealthy Volunteers

Phase 1

A Study to Assess the Drug Interaction Between MYK-224 and Itraconazole and Verapamil in Healthy Participants

CompletedNCT05304533

Bristol-Myers SquibbHealthy Participants

Start: 2022-04-21End: 2022-11-29Updated: 2023-01-13

A Study to Evaluate the Safety, Tolerability, and Drug Levels of MYK-224 Administered in Single and Multiple Doses in Healthy Adult Japanese Participants

CompletedNCT05405543

Bristol-Myers SquibbHealthy Volunteers

Start: 2022-07-12End: 2022-12-09Updated: 2023-01-13

A Study to Evaluate the Absorption, Metabolism, and Excretion (ADME) of BMS-986435

CompletedNCT05686096

Bristol-Myers SquibbHealthy Volunteers

Start: 2023-01-16End: 2023-04-08Updated: 2023-05-25

Phase 2

A Study to Evaluate the Efficacy, Safety, and Tolerability of MYK-224 in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

TerminatedNCT05556343

Bristol-Myers SquibbCardiomyopathy, Hypertrophic

Start: 2023-01-18End: 2025-02-27Updated: 2026-06-02