Metyrapone 250 mg Oral Tablets

DRUG4 trials

Sponsors

Eleonora Seelig, Mayo Clinic, Laikο General Hospital, Athens

Conditions

Autonomous Cortisol Secretion (ACS)Glucocorticoid EffectMild Autonomous Cortisol Secretion (MACS)

Early Phase 1

Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals

CompletedNCT05167084

Eleonora SeeligGlucocorticoid Effect

Start: 2022-02-08End: 2023-06-08Updated: 2023-08-23

The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)

CompletedNCT05919992

Eleonora SeeligGlucocorticoid Effect

Start: 2023-05-15End: 2024-07-25Updated: 2024-08-14

Phase 2

Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS

Not yet recruitingNCT07138274

Mayo ClinicAutonomous Cortisol Secretion (ACS), Mild Autonomous Cortisol Secretion (MACS)

Start: 2026-04-30End: 2031-12-31Target: 90Updated: 2025-08-22

Phase 4

Metyrapone Versus Osilodrostat in Patients With Metabolic Autonomous Cortisol Secretion (MACS)

RecruitingNCT07268222

Laikο General Hospital, AthensMild Autonomous Cortisol Secretion (MACS)

Start: 2025-12-01End: 2027-11-25Target: 150Updated: 2025-12-05