Low-dose aspirin

DRUG15 trials

Sponsors

PharmaEssentia Japan K.K., Assiut University, Dr. Graeme Smith, Xijing Hospital, Women and Infants Hospital of Rhode Island

Conditions

Acute Coronary SyndromeBreast CarcinomaCardiovascular DiseasesChronic Coronary DiseaseEclampsiaEndometrial CarcinomaEssential ThrombocythemiaGestational Hypertension

Early Phase 1

Postpartum Low-Dose Aspirin After Preeclampsia for Optimization of Cardiovascular Risk (PAPVASC)

TerminatedNCT04243278

Dr. Graeme SmithCardiovascular Diseases, Preeclampsia Severe, Primary Prevention

Start: 2020-09-14End: 2022-12-31Updated: 2024-04-05

Phase 2

Efficacy and Safety of P1101 in Polycythemia Vera Patients for Whom the Standard of Treatment is Difficult to Apply

CompletedNCT04182100

PharmaEssentia Japan K.K.Polycythemia Vera (PV)

Start: 2019-12-20End: 2021-03-08Updated: 2025-09-15

Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

RecruitingNCT05557877

Mayo ClinicBreast Carcinoma

Start: 2023-03-09End: 2027-01-30Target: 100Updated: 2026-03-31

Aspirin Dose Comparison in Elderly PCI Patients: 30mg vs. 75mg in Acute Coronary Syndrome

RecruitingNCT06254391

Medical University of WarsawAcute Coronary Syndrome, Myocardial Infarction

Start: 2023-07-03End: 2025-07-31Target: 40Updated: 2024-02-12

Phase 3

AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positive Myeloproliferative Neoplasms

RecruitingNCT05198960

University Hospital, BrestEssential Thrombocythemia, High-risk Patients, JAK2 V617F +2

Start: 2022-07-13End: 2027-07-13Target: 1308Updated: 2026-03-20

Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE)

CompletedNCT05253781

University of Lagos, NigeriaIntrauterine Growth Restriction, Preeclampsia, Pregnancy Complications +1

Start: 2020-07-01End: 2024-11-21Updated: 2025-01-09

One-Month DAPT in CABG Patients

RecruitingNCT05997693

Weill Medical College of Cornell UniversityChronic Coronary Disease

Start: 2024-08-15End: 2031-01-31Target: 700Updated: 2025-12-22

A Study to Evaluate P1101 in Japanese PV Patients

CompletedNCT06002490

PharmaEssentia Japan K.K.Polycythemia Vera (PV)

Start: 2023-10-17End: 2024-07-26Updated: 2024-11-08

Phase 4

Low-dose Aspirin Therapy in Patients With Ischemic Stroke and Microbleeds

Xijing HospitalIschemic Stroke

Start: 2020-10-01End: 2022-08-31Target: 400Updated: 2022-02-09

Adherence to Universal Aspirin Compared to Screening Indicated Aspirin for Prevention of Preeclampsia

WithdrawnNCT04797949

Women and Infants Hospital of Rhode IslandMedication Adherence, Preeclampsia

Start: 2021-03-03End: 2022-06-01Updated: 2025-04-04

Treatment With Aspirin After Preeclampsia: TAP Trial

RecruitingNCT06281665

Malamo CountourisCardiovascular Diseases, Eclampsia, Gestational Hypertension +8

Start: 2024-05-29End: 2027-06-01Target: 60Updated: 2026-02-05

Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain

Not yet recruitingNCT07281547

Mayo ClinicEndometrial Carcinoma

Start: 2026-08-12End: 2027-06-11Target: 25Updated: 2026-02-18

Unknown Phase

Hydroxychloroquine and Unexplained Recurrent Miscarriage

CompletedNCT04228263

Assiut UniversityUnexplained Recurrent Miscarriage

Start: 2020-01-01End: 2023-07-08Updated: 2023-12-07

Hydroxychloroquine in Prevention of Preeclampsia

CompletedNCT04755322

Assiut UniversityPreeclampsia

Start: 2021-03-01End: 2023-07-30Updated: 2023-12-08

The Investigation of the Prediction Model and Prevention Strategy of Serious Pregnancy Complications in Hypertensive Disorders of Pregnancy Based on the Chinese Population

Women's Hospital School Of Medicine Zhejiang UniversityHypertensive Disorder of Pregnancy, Pregnancy Complications

Start: 2021-11-30End: 2024-12-30Target: 4500Updated: 2021-12-02

Related Papers

Efficacy and safety of a three-step dose escalation regimen of ropeginterferon alfa-2b in Japanese patients with polycythemia vera: a phase 3b, single-arm, multicenter study.

2026-03-09

Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy in Nigeria (PIPSICKLE): a randomised controlled trial.

2026-03-01

Increased risk of venous thromboembolism and hypertensive disorders during pregnancy in sickle cell disease patients: A meta-analysis focused on actionable outcomes

Blood2025-11-03

Population Pharmacokinetics‐Pharmacodynamics and Exposure‐Response of Ropeginterferon Alfa‐2b in Chinese and Japanese Patients With Polycythemia Vera

Pharmacology Research & Perspectives2025-05-015 citations

One-month DAPT with ticagrelor and aspirin for patients undergoing coronary artery bypass grafting: rationale and design of the randomised, multicentre, double-blind, placebo-controlled ODIN trial

EuroIntervention2024-03-017 citations

P1007: PHASE 2, OPEN-LABEL, MULTICENTER, SINGLE-ARM STUDY INVESTIGATING THE EFFICACY AND SAFETY OF ROPEGINTERFERON ALFA-2B IN JAPANESE PATIENTS WITH POLYCYTHEMIA VERA

HemaSphere2022-06-01

The Rationale, Design, and Baseline Characteristics of a Phase 2 Study to Evaluate the Safety and Efficacy of Ropeginterferon Alfa-2b (P1101) in Japanese Patients with Polycythemia Vera for Whom the Current Standard of Care Is Difficult to Apply

Blood2020-11-042 citations