Lipopolysaccharide (LPS)

BIOLOGICAL5 trials

Sponsors

University of California, Los Angeles, Janssen Research & Development, LLC, Universitaire Ziekenhuizen KU Leuven

Conditions

DepressionEndotoxemiaExecutive Function (Cognition)HealthyHealthy VolunteerInflammationStress

Early Phase 1

Leucine for Depression Study (L-DEP)

TerminatedNCT03557684

University of California, Los AngelesDepression

Start: 2018-09-01End: 2021-07-31Updated: 2023-06-08

Theophylline for Depression Study

WithdrawnNCT04309877

University of California, Los AngelesDepression

Start: 2023-03-31End: 2025-06-30Updated: 2021-11-05

Phase 1

A Study of Adalimumab on Inflammatory Mediators Following a Systemic Endotoxin Challenge

CompletedNCT05884242

Janssen Research & Development, LLCHealthy

Start: 2023-05-22End: 2023-08-07Updated: 2025-03-30

Unknown Phase

Mapping the Effect of (neuro)inflammation on Stress Sensitivity in the Brain of Healthy Men

RecruitingNCT06620679

Universitaire Ziekenhuizen KU LeuvenHealthy Volunteer, Inflammation, Stress

Start: 2024-05-03End: 2026-12-31Target: 20Updated: 2024-10-01

Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function

RecruitingNCT07713641

Universitaire Ziekenhuizen KU LeuvenEndotoxemia, Executive Function (Cognition), Inflammation

Start: 2025-10-24End: 2027-03-30Target: 56Updated: 2026-07-20