Linaclotide 290 micrograms

DRUG7 trials

Conditions

Chronic ConstipationConstipationCystic Fibrosis (CF)Irritable Bowel Syndrome Characterized by ConstipationOpioid-Induced Constipation

Early Phase 1

Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis

RecruitingNCT07569419

University of NottinghamCystic Fibrosis (CF)

Start: 2026-03-09End: 2026-10-01Target: 26Updated: 2026-05-06

Phase 2

Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer Pain

CompletedNCT02270983

Forest LaboratoriesOpioid-Induced Constipation

Start: 2014-10-31End: 2015-10-31Updated: 2019-04-08

Phase 3

Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic Constipation

CompletedNCT00765882

Forest LaboratoriesChronic Constipation

Start: 2008-09-30End: 2009-08-31Updated: 2013-01-30

Trial of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation

CompletedNCT00948818

Forest LaboratoriesIrritable Bowel Syndrome Characterized by Constipation

Start: 2009-07-31End: 2010-08-31Updated: 2013-01-30

Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating

CompletedNCT01642914

Forest LaboratoriesChronic Constipation, Constipation

Start: 2012-08-31End: 2013-08-31Updated: 2016-04-26

Phase 4

Effect to Linaclotide on Colonic Motility

CompletedNCT06989268

Universitaire Ziekenhuizen KU LeuvenChronic Constipation

Start: 2014-02-10End: 2015-06-03Updated: 2025-05-25

Unknown Phase

MRI Parameters as Biomarkers in Cystic Fibrosis (FEMPTO)

Not yet recruitingNCT07780344

University of NottinghamCystic Fibrosis (CF)

Start: 2026-09-01End: 2027-08-01Target: 12Updated: 2026-08-21

The American Journal of Gastroenterology2023-10-01

S524 Predictors of Placebo Response in Patients With Irritable Bowel Syndrome and Constipation: A Post-Hoc Analysis From Pooled Phase 2b/3 Studies Assessing the Safety and Efficacy of Linaclotide

The American Journal of Gastroenterology2022-10-01

S510 Time to Relief of Key Abdominal and Bowel Symptoms of Irritable Bowel Syndrome with Constipation: A Post-Hoc Analysis of Randomized Controlled Trials of Linaclotide

The American Journal of Gastroenterology2021-10-011 citations

S529 Linaclotide Improves Symptoms of Irritable Bowel Syndrome With Constipation, Irrespective of Severity and Age: A Post-Hoc Analysis of Pooled Trials

The American Journal of Gastroenterology2021-10-01

Lessons learned: Chronic idiopathic constipation patient experiences with over-the-counter medications

PLoS ONE2021-01-1115 citations

Efficacy and safety of linaclotide for opioid-induced constipation in patients with chronic noncancer pain syndromes from a phase 2 randomized study

Pain2020-03-3113 citations

Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial

PLoS ONE2015-07-2979 citations

The impact of abdominal pain on global measures in patients with chronic idiopathic constipation, before and after treatment with linaclotide: a pooled analysis of two randomised, double‐blind, placebo‐controlled, phase 3 trials

Alimentary Pharmacology & Therapeutics2014-10-1328 citations

Effect of linaclotide on severe abdominal symptoms in patients with irritable bowel syndrome with constipation.

2013-09-2546 citations

Randomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints.

2012-11-0193 citations

Two randomized trials of linaclotide for chronic constipation.

2011-08-01258 citations