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Linaclotide 145 micrograms

DRUG4 trials

Sponsors

Forest Laboratories, Md Mehedi Shahriar

Conditions

CICChronic ConstipationChronic Idiopathic ConstipationConstipationConstipation Predominant Irritable Bowel SyndromeIrritable Bowel Syndrome (IBS-C)Opioid-Induced Constipation

Phase 2

Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer Pain
CompletedNCT02270983
Forest LaboratoriesOpioid-Induced Constipation
Start: 2014-10-31End: 2015-10-31Updated: 2019-04-08

Phase 3

Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic Constipation
CompletedNCT00765882
Forest LaboratoriesChronic Constipation
Start: 2008-09-30End: 2009-08-31Updated: 2013-01-30
Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating
CompletedNCT01642914
Forest LaboratoriesChronic Constipation, Constipation
Start: 2012-08-31End: 2013-08-31Updated: 2016-04-26

Phase 4

"Efficacy and Safety of Linaclotide in Chronic Constipation"
Not yet recruitingNCT07431957
Md Mehedi ShahriarChronic Constipation, Chronic Idiopathic Constipation, CIC +2
Start: 2026-02-20End: 2027-01-31Target: 90Updated: 2026-02-25

Related Papers

S687 Linaclotide Improves Abdominal Symptoms Over Placebo in Patients With Chronic Idiopathic Constipation: A Pooled Analysis
The American Journal of Gastroenterology2023-10-01
Lessons learned: Chronic idiopathic constipation patient experiences with over-the-counter medications
PLoS ONE2021-01-1115 citations
Efficacy and safety of linaclotide for opioid-induced constipation in patients with chronic noncancer pain syndromes from a phase 2 randomized study
Pain2020-03-3113 citations
Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial
PLoS ONE2015-07-2979 citations
The impact of abdominal pain on global measures in patients with chronic idiopathic constipation, before and after treatment with linaclotide: a pooled analysis of two randomised, double‐blind, placebo‐controlled, phase 3 trials
Alimentary Pharmacology & Therapeutics2014-10-1328 citations
Two randomized trials of linaclotide for chronic constipation.
2011-08-01258 citations