L-asparaginase

DRUG19 trials

Sponsors

Children's Oncology Group, Japan Adult Leukemia Study Group, Rutgers, The State University of New Jersey, St. Jude Children's Research Hospital, PETHEMA Foundation

Conditions

Acute Leukemia of Ambiguous LineageAcute Lymphobkastic LeukemiaAcute Lymphoblastic LeukemiaAcute Lymphoblastic Leukemia (ALL)Acute Lymphoblastic Leukemia, in RelapseAcute Lymphocytic LeukemiaB Lymphoblastic LeukemiaB-cell Adult Acute Lymphoblastic Leukemia

Phase 1

Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL)

CompletedNCT00098839

Children's Oncology GroupRecurrent Childhood Acute Lymphoblastic Leukemia

Start: 2005-02-28End: 2011-04-30Updated: 2017-12-12

Phase 2

Applying Pediatric Regimens to Younger Adult Patients With Acute Lymphoblastic Leukemia (ALL)

Japan Adult Leukemia Study GroupLymphoblastic Leukemia, Acute

Start: 2002-09-30End: 2011-09-30Target: 120Updated: 2008-11-14

CINJALL: Treatment for Children With Acute Lymphocytic Leukemia

CompletedNCT00176462

Rutgers, The State University of New JerseyAcute Lymphocytic Leukemia

Start: 2001-02-28End: 2008-09-30Updated: 2014-06-09

L-asparaginase Monotherapy as Salvage Treatment in Patients With NK/T Cell Lymphoma

CompletedNCT00854425

Fudan UniversityLymphoma

Start: 2008-06-30End: 2012-01-31Updated: 2012-02-20

Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

CompletedNCT00873093

National Cancer Institute (NCI)B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia, Recurrent Adult Acute Lymphoblastic Leukemia +5

Start: 2009-03-31End: 2014-09-30Updated: 2017-01-27

GRASPA (Erythrocytes Encapsulating L-asparaginase) in Patients With Relapse of Acute Lymphoblastic Leukemia

CompletedNCT01518517

ERYtech PharmaAcute Lymphoblastic Leukemia, in Relapse

Start: 2009-12-31End: 2016-10-31Updated: 2022-02-02

VP-16, Ifosfamide, Dexamethasone, L-asparaginase Chemotherapy in Patients With Extranodal Natural Killer T Cell Lymphoma (VIDL+ASCT)

Samsung Medical CenterExtranodal NK-T-Cell Lymphoma

Start: 2016-02-21End: 2021-11-30Target: 27Updated: 2020-10-22

Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage

RecruitingNCT04440267

Institute of Hematology & Blood Diseases Hospital, ChinaAcute Leukemia of Ambiguous Lineage

Start: 2020-07-08End: 2027-12-20Target: 50Updated: 2025-08-06

Ma-Spore ALL 2020 Study

RecruitingNCT06336395

National University Hospital, SingaporeB Lymphoblastic Leukemia

Start: 2020-03-04End: 2030-03-31Target: 500Updated: 2024-03-28

Phase 3

High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL)

Japan Adult Leukemia Study GroupLymphoblastic Leukemia, Acute

Start: 2002-09-30End: 2011-09-30Target: 240Updated: 2008-11-14

SIMPLE Chemotherapy for NK Lymphoma/Leukaemia

The University of Hong KongNatural Killer/T-Cell Lymphoma, Nasal and Nasal-Type, Non-Hodgkin's Lymphoma, Relapsed, Non-Hodgkin T-cell Lymphoma

Start: 2017-07-01End: 2020-06-30Target: 68Updated: 2018-08-14

Phase 4

LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive

CompletedNCT00526305

PETHEMA FoundationAcute Lymphoblastic Leukemia

Start: 2000-01-31End: 2005-04-30Target: 100Updated: 2010-01-05

LAL-BR/2001: Study Treatment to Low Risk ALL

CompletedNCT00526175

PETHEMA FoundationAcute Lymphoblastic Leukemia

Start: 2001-06-30End: 2015-12-31Target: 150Updated: 2016-01-20

LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia

CompletedNCT00526409

PETHEMA FoundationAcute Lymphoblastic Leukemia

Start: 2005-06-30End: 2014-10-31Target: 40Updated: 2014-10-28

Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia

CompletedNCT01358253

Ruijin HospitalAcute Lymphoblastic Leukemia

Start: 2010-12-31End: 2012-12-31Updated: 2014-05-20

Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia

CompletedNCT02036489

PETHEMA FoundationAcute Lymphobkastic Leukemia

Start: 2008-01-31End: 2019-12-01Updated: 2020-03-05

Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study

National University Hospital, SingaporeAcute Lymphoblastic Leukemia (ALL)

Start: 2008-10-31Target: 500Updated: 2016-09-30

Combination Chemotherapy Including Cisplatin, Ifosfamide, Gemcitabine, L-asparaginase, Etoposide and Dexamethasone as Treatment of Newly Diagnosed and Relapsed/Refractory Peripheral T Cell Lymphomas

The University of Hong KongPeripheral T Cell Lymphoma

Start: 2017-02-24End: 2022-02-28Target: 50Updated: 2018-06-11

Unknown Phase

Treatment for Patients With Stage III or IV Non-Hodgkin Lymphoma

CompletedNCT00187122

St. Jude Children's Research HospitalLymphoblastic Lymphoma

Start: 1993-03-31End: 2004-06-30Updated: 2008-04-23

Related Papers

A Phase II Prospective Study Evaluating an L-Asparaginase Regimen, Simple, in Newly Diagnosed Extranodal NK/T Cell Lymphoma

Blood2024-11-051 citations

Asciminib Maintains Antibody-Dependent Cellular Cytotoxicity against Leukemic Blasts

Cancers2024-03-26

Open-label, single arm, multicenter phase II study of VIDL induction chemotherapy followed by upfront autologous stem cell transplantation in patients with advanced stage extranodal NK/T-cell lymphoma.

2020-12-0413 citations

NOR-GRASPALL2016 (NCT03267030): Asparaginase Encapsulated in Erythrocytes (eryaspase) - a Promising Alternative to Peg-Asparaginase in Case of Hypersensitivity

Blood2020-11-056 citations

Bortezomib reinduction chemotherapy in high-risk ALL in first relapse: a report from the Children's Oncology Group.

2019-04-0777 citations

Pharmacodynamic characterization of eryaspase (L-asparaginase encapsulated in red blood cells) in combination with chemotherapy in a phase 2/3 trial in patients with relapsed acute lymphoblastic leukemia (NCT01518517).

Journal of Clinical Oncology2018-05-202 citations

Population Pharmacokinetic Analysis of Bortezomib in Pediatric Leukemia Patients: Model-Based Support for Body Surface Area-Based Dosing Over the 2- to 16-Year Age Range

The Journal of Clinical Pharmacology2017-04-1817 citations

Drug monitoring of ERY001 (erythrocyte encapsulated L-asparaginase) and native L-asparaginase (L-ASP) in combination with COOPRALL regimen in Phase 3 randomized trial in patients with relapsed acute lymphoblastic leukemia.

Journal of Clinical Oncology2015-05-205 citations