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Ketone Monoester (KE)

DIETARY_SUPPLEMENT7 trials

Sponsors

The University of Texas Health Science Center at San Antonio, University of British Columbia, University of Bath, Jessa Hospital, University of Alabama at Birmingham

Conditions

Acute Heart Failure (AHF)Cardiogenic ShockExercise-induced Myocardial DamageHealthy (Controls)Heart FailureHeart Failure, Reduced Ejection FractionHistone Deacetylase (HDAC) ActivityImmune Functions

Early Phase 1

Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
RecruitingNCT06108076
The University of Texas Health Science Center at San AntonioHeart Failure, Reduced Ejection Fraction, Type 2 Diabetes
Start: 2024-01-16End: 2026-12-31Target: 10Updated: 2026-01-21

Phase 4

Effects of Exogenous Ketones on Acute Changes and Recovery of the Heart Muscle After Intense Exercise.
RecruitingNCT06715748
Jessa HospitalExercise-induced Myocardial Damage, Right Ventricular Diastolic Dysfunction
Start: 2024-10-17End: 2026-12-22Target: 30Updated: 2024-12-04
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
RecruitingNCT07527156
Institute for Clinical and Experimental MedicineAcute Heart Failure (AHF), Cardiogenic Shock, Heart Failure +2
Start: 2026-04-04End: 2027-03-31Target: 12Updated: 2026-04-14

Unknown Phase

The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation
RecruitingNCT06590623
University of British ColumbiaHistone Deacetylase (HDAC) Activity, Immune Functions, Ketosis, Metabolic
Start: 2024-10-01End: 2025-06-01Target: 12Updated: 2025-03-07
The Causal Role of Ketone Bodies in Obesity-associated Disease Prevention - Combining Genetic Epidemiology With a Randomised Trial to Infer Causality
CompletedNCT06668168
University of BathNutrition, Obesity and Overweight
Start: 2025-05-06End: 2026-06-03Updated: 2026-06-15
The Effects of Exogenous Ketones on Cognitive Function
RecruitingNCT07051655
University of Alabama at BirminghamKetone Monoester, Placebo - Control
Start: 2025-12-01End: 2027-07-31Target: 45Updated: 2026-07-13
Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?
RecruitingNCT07546409
University of Alabama at BirminghamHealthy (Controls), Prediabetes
Start: 2025-05-20End: 2027-05-31Target: 20Updated: 2026-07-02