Jakavi 5 mg tablets
Sponsors
Incyte Corp., Assistance Publique Hopitaux De Paris, Karyopharm Therapeutics Inc., AbbVie Deutschland GmbH & Co. KG, Takeda Development Center Americas Inc.
Conditions
Adult patients older than 18 years. Patients admitted to the participating ICUs will be included in this study if the meet eligibility criteria.Advanced malignancies and IAI diseasesDIPSS-Intermediate or High Risk MyelofibrosisFramework for OptimizingJAK inhibitor-naïve myelofibrosisMyelofibrosisMyeloproliferative NeoplasmsPolycythaemia Vera (PV)
Phase 1
A Phase 1b/2 Study of BMS-986158 Monotherapy and in Combination with Either Ruxolitinib or Fedratinib in Participants with DIPSS-Intermediate or High Risk Myelofibrosis
Active, not recruitingCTIS2023-509635-89-00
Start: 2021-06-01Target: 132Updated: 2026-01-12
A Phase 1 Open-Label Study Evaluating the Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination with Ruxolitinib in Myeloproliferative Neoplasm Subjects, Incorporating Extension Part 6 – Continued Access for Navitoclax to Roll Over Subjects in France and Bulgaria from Studies M16-191 and M20-178
Active, not recruitingCTIS2023-507274-40-00
Start: 2021-04-22Target: 60Updated: 2025-09-12
Phase 2
INCB 50465-801:
A Phase 2, Open-Label, Multicenter, Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Parsaclisib (INCB050465)
RecruitingCTIS2022-501687-18-00
Start: 2020-10-28Target: 62Updated: 2025-07-07
JAKAHDI - JAK inhibitors in acquired hemophagocytic syndrome in the ICU
RecruitingCTIS2023-504513-77-00
Start: 2024-09-16Target: 42Updated: 2023-10-10
An Open-Label, Multicenter, Rollover Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib
RecruitingCTIS2023-507225-42-00
Start: 2024-11-05Target: 6Updated: 2025-08-05
A Phase 2 study to evaluate the efficacy and safety of selinexor monotherapy in subjects
with JAK inhibitor-naïve myelofibrosis and moderate thrombocytopenia.
RecruitingCTIS2024-511309-47-00
Start: 2024-07-17Target: 38Updated: 2026-01-27
Ruxolitinib versus Best Available Therapy in patients with high-risk polycythemia vera or high-risk essential thrombocythemia – The Ruxo-BEAT Trial
Active, not recruitingCTIS2024-515619-23-00
Start: 2015-06-29Target: 223Updated: 2025-09-01
An Open-Label Clinical Trial of RVU120 as Monotherapy and in Combination with Ruxolitinib in Patients with Intermediate or High-Risk, Primary or Secondary Myelofibrosis (POTAMI-61)
RecruitingCTIS2024-511688-27-00
Start: 2024-09-19Target: 83Updated: 2025-12-16
A Phase 2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of KER-050 as Monotherapy or in Combination with Ruxolitinib in Participants with Myelofibrosis.
Active, not recruitingCTIS2023-507468-38-00
Start: 2022-04-22Target: 47Updated: 2025-12-16
INCA34176-254: A Phase 2, Open-Label, Randomized, Multicenter Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease
RecruitingCTIS2022-502168-19-00
Start: 2024-10-22Target: 70Updated: 2026-01-23
Combination Therapy with Interferon-Alpha2a and Ruxolitinib in Newly Diagnosed Patients with Polycythemia Vera.
A Danish Safety and Efficacy Study.
Not yet recruitingCTIS2024-518216-39-00
Target: 25Updated: 2024-11-04
R-HLH - Efficacy of Ruxolitinib as first line treatment in primary haemophagocytic lymphohistiocytosis (HLH) in children: a Phase 2, multicentre, non-comparative study
RecruitingCTIS2024-516105-23-01
Start: 2024-11-10Target: 20Updated: 2024-12-16
Framework for Optimizing, Refining, and Unifying Management of HSCT in Pediatric ALL.
RecruitingCTIS2025-522052-13-00
Start: 2025-12-24Target: 735Updated: 2025-11-24
Phase 3
A PHASE 1/3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF SELINEXOR, A SELECTIVE INHIBITOR OF NUCLEAR EXPORT, IN COMBINATION WITH RUXOLITINIB IN TREATMENT-NAÏVE PATIENTS WITH MYELOFIBROSIS
Active, not recruitingCTIS2023-506139-13-00
Start: 2024-01-04Target: 195Updated: 2025-10-09
MITHRIDATE: A phase III, randomised, open-label, Multicenter International Trial comparing ruxolitinib with either HydRoxycarbamIDe or interferon Alpha as first line ThErapy for high risk polycythemia vera
RecruitingCTIS2024-516109-21-00
Start: 2024-12-09Target: 293Updated: 2025-04-29