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Jakavi 5 mg tablets

DRUG16 trials

Sponsors

Incyte Corp., Assistance Publique Hopitaux De Paris, Karyopharm Therapeutics Inc., AbbVie Deutschland GmbH & Co. KG, Takeda Development Center Americas Inc.

Conditions

Adult patients older than 18 years. Patients admitted to the participating ICUs will be included in this study if the meet eligibility criteria.Advanced malignancies and IAI diseasesDIPSS-Intermediate or High Risk MyelofibrosisFramework for OptimizingJAK inhibitor-naïve myelofibrosisMyelofibrosisMyeloproliferative NeoplasmsPolycythaemia Vera (PV)

Phase 1

Phase 2

INCB 50465-801: A Phase 2, Open-Label, Multicenter, Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Parsaclisib (INCB050465)
RecruitingCTIS2022-501687-18-00
Incyte Corp.Advanced malignancies and IAI diseases
Start: 2020-10-28Target: 62Updated: 2025-07-07
JAKAHDI - JAK inhibitors in acquired hemophagocytic syndrome in the ICU
RecruitingCTIS2023-504513-77-00
Assistance Publique Hopitaux De ParisAdult patients older than 18 years. Patients admitted to the participating ICUs will be included in this study if the meet eligibility criteria.
Start: 2024-09-16Target: 42Updated: 2023-10-10
An Open-Label, Multicenter, Rollover Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib
RecruitingCTIS2023-507225-42-00
Incyte Corp.Myelofibrosis
Start: 2024-11-05Target: 6Updated: 2025-08-05
A Phase 2 study to evaluate the efficacy and safety of selinexor monotherapy in subjects with JAK inhibitor-naïve myelofibrosis and moderate thrombocytopenia.
RecruitingCTIS2024-511309-47-00
Karyopharm Therapeutics Inc.JAK inhibitor-naïve myelofibrosis, moderate thrombocytopenia
Start: 2024-07-17Target: 38Updated: 2026-01-27
Ruxolitinib versus Best Available Therapy in patients with high-risk polycythemia vera or high-risk essential thrombocythemia – The Ruxo-BEAT Trial
Active, not recruitingCTIS2024-515619-23-00
Universitaetsklinikum Aachen AöRessential thrombocythemia, polycythemia vera
Start: 2015-06-29Target: 223Updated: 2025-09-01
An Open-Label Clinical Trial of RVU120 as Monotherapy and in Combination with Ruxolitinib in Patients with Intermediate or High-Risk, Primary or Secondary Myelofibrosis (POTAMI-61)
RecruitingCTIS2024-511688-27-00
Ryvu Therapeutics S.A.Myelofibrosis
Start: 2024-09-19Target: 83Updated: 2025-12-16
A Phase 2 Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of KER-050 as Monotherapy or in Combination with Ruxolitinib in Participants with Myelofibrosis.
Active, not recruitingCTIS2023-507468-38-00
Takeda Development Center Americas Inc.Myelofibrosis
Start: 2022-04-22Target: 47Updated: 2025-12-16
INCA34176-254: A Phase 2, Open-Label, Randomized, Multicenter Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease
RecruitingCTIS2022-502168-19-00
Incyte Corp.chronic graft-versus-host disease
Start: 2024-10-22Target: 70Updated: 2026-01-23
Combination Therapy with Interferon-Alpha2a and Ruxolitinib in Newly Diagnosed Patients with Polycythemia Vera. A Danish Safety and Efficacy Study.
Not yet recruitingCTIS2024-518216-39-00
Region SjaellandPolycythemia
Target: 25Updated: 2024-11-04
R-HLH - Efficacy of Ruxolitinib as first line treatment in primary haemophagocytic lymphohistiocytosis (HLH) in children: a Phase 2, multicentre, non-comparative study
RecruitingCTIS2024-516105-23-01
Assistance Publique Hopitaux De Parishaemophagocytic lymphohistiocytosis (HLH) in children
Start: 2024-11-10Target: 20Updated: 2024-12-16
Framework for Optimizing, Refining, and Unifying Management of HSCT in Pediatric ALL.
RecruitingCTIS2025-522052-13-00
Ospedale Pediatrico Bambino Gesuand Unifying Management of HSCT in Pediatric ALL, Framework for Optimizing, Refining
Start: 2025-12-24Target: 735Updated: 2025-11-24

Phase 3

Phase 4