Islet Transplantation

PROCEDURE13 trials

Sponsors

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), Rodolfo Alejandro, University Hospital, Lille, University Hospital, Geneva

Conditions

Diabetes MellitusDiabetes Mellitus Type 1Diabetes Mellitus, Insulin-DependentDiabetes Mellitus, Type 1HypoglycemiaHypoglycemia UnawarenessImmunosuppressionKidney Transplant

Phase 1

Islet Transplantation for Patients With Type 1 Diabetes

CompletedNCT00073281

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Diabetes Mellitus, Type 1

Start: 2003-08-31End: 2004-12-31Target: 10Updated: 2010-01-15

Islet of Langerhans Graft Monitoring by Magnetic Resonance Imaging

TerminatedNCT00453817

University Hospital, GenevaType 1 Diabetes Mellitus

Start: 2005-06-30End: 2010-06-30Updated: 2014-12-02

Islet After Kidney Transplantation (IAK) in Patients With Type 1 Diabetes

CompletedNCT00708604

City of Hope Medical CenterDiabetes Mellitus

Start: 2005-08-31End: 2014-06-30Updated: 2014-07-04

Allogeneic Islet Cells Transplanted Onto the Omentum

CompletedNCT02213003

Rodolfo AlejandroHypoglycemia, Hypoglycemia Unawareness, Type 1 Diabetes Mellitus

Start: 2014-09-30End: 2024-06-30Updated: 2025-08-12

Phase 2

Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression

CompletedNCT00006505

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Diabetes Mellitus Type 1

Start: 2000-11-16End: 2020-04-21Updated: 2021-04-20

Islet Transplantation for Type 1 Diabetes

CompletedNCT00014911

National Institute of Allergy and Infectious Diseases (NIAID)Diabetes Mellitus, Insulin-Dependent

Start: 2001-04-30End: 2010-08-31Updated: 2017-03-15

Steroid-free and Long-term Calcineurin-free Trial in Islet Cell Transplantation

CompletedNCT00315627

Rodolfo AlejandroType 1 Diabetes Mellitus

Start: 2005-07-31End: 2014-01-31Updated: 2017-05-25

Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation

CompletedNCT00315588

Rodolfo AlejandroDiabetes Mellitus, Type 1

Start: 2000-12-31End: 2014-05-31Updated: 2017-04-12

Islet Allotransplantation With Steroid Free Immunosuppression

CompletedNCT00446264

University Hospital, LilleHypoglycemia, Metabolic Diseases, Type 1 Diabetes

Start: 2003-05-31End: 2009-02-28Updated: 2012-04-27

Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant

CompletedNCT02464878

Massachusetts General HospitalKidney Transplant, Type 1 Diabetes

Start: 2017-01-31End: 2022-12-31Updated: 2023-12-22

Phase 3

Islet Transplantation in Type 1 Diabetes

CompletedNCT00434811

National Institute of Allergy and Infectious Diseases (NIAID)Type 1 Diabetes Mellitus

Start: 2006-10-31End: 2014-05-31Updated: 2019-07-17

Efficacy of Islet After Kidney Transplantation

CompletedNCT00468117

National Institute of Allergy and Infectious Diseases (NIAID)Type 1 Diabetes Mellitus

Start: 2007-01-31End: 2017-07-05Updated: 2017-10-20

Unknown Phase

Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation

CompletedNCT01123187

University Hospital, LilleImmunosuppression, Organ Transplantation, Type 1 Diabetes

Start: 2003-03-31End: 2016-04-30Updated: 2025-11-28

Related Papers

Identifying Promising Immunomodulators for Type 1 Diabetes (T1D) and Islet Transplantation.

2024-12-204 citations

Insulin-mimetic effects of short-term rapamycin in type 1 diabetic patients prior to islet transplantation.

2018-04-136 citations

Purity of islet preparations and 5-year metabolic outcome of allogenic islet transplantation

American Journal of Transplantation2017-09-2333 citations

Human Islet Cell Transplantation Successful in Patients with Type 1 Diabetes Who Have SH

MD Conference Express2014-07-01

Continuous glucose monitoring after islet transplantation in type 1 diabetes: an excellent graft function (β-score greater than 7) Is required to abrogate hyperglycemia, whereas a minimal function is necessary to suppress severe hypoglycemia (β-score greater than 3).

2012-09-2077 citations