Intrathecal methotrexate

DRUG7 trials

Conditions

Brain MetastasesBreast NeoplasmsDLBCLLeptomeningeal MetastasisLeukaemia,LymphoblasticLymphoblastic LeukemiaLymphoblastic LymphomaLymphoma, B Cell

Early Phase 1

Intrathecal Methotrexate for Progressive Multiple Sclerosis: An Open Label Single Arm Study

NCT02644044

Tel-Aviv Sourasky Medical CenterTo Evaluate the Effect of Therapy With IT MTX on the Disease Course of Patients With Progressive MS

Start: 2016-01-31End: 2018-01-31Target: 30Updated: 2015-12-31

Phase 2

Phase II Study of Combined Modality Treatment in Primary Testicular Non-Hodgkin's Lymphoma

CompletedNCT00210379

International Extranodal Lymphoma Study Group (IELSG)Lymphoma, B Cell

Start: 2000-11-30End: 2007-03-31Updated: 2009-07-22

Augmented Berlin-Frankfurt-Munster (BFM) Therapy for Adolescent/Young Adults With Acute Lymphoblastic Leukemia or Acute Lymphoblastic Lymphoma

CompletedNCT00866749

M.D. Anderson Cancer CenterLymphoblastic Leukemia, Lymphoblastic Lymphoma

Start: 2006-09-12End: 2018-07-26Updated: 2019-09-10

Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis

CompletedNCT01281696

National Taiwan University HospitalBrain Metastases, Breast Neoplasms, Leptomeningeal Metastasis

Start: 2011-01-31End: 2013-10-31Updated: 2013-10-16

Modified MRCUKALLⅫ/ECOGE2993 Regimen for ALL

NCT02660762

Sun Yat-sen UniversityLeukaemia,Lymphoblastic

Start: 2016-01-31End: 2019-01-31Target: 100Updated: 2017-06-19

Phase 3

High-dose Intravenous Methotrexate Versus Intrathecal Methotrexate for Central Nervous System Prophylaxis in DLBCL

NCT03123718

Chonnam National University HospitalDLBCL

Start: 2017-07-01End: 2021-06-30Target: 205Updated: 2017-04-24

Phase 4

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

CompletedNCT00029523

Pacira Pharmaceuticals, IncMeningeal Neoplasms

Start: 2001-04-30End: 2004-11-30Target: 100Updated: 2007-02-28

Related Papers

Intrathecal methotrexate in progressive multiple sclerosis: a phase 1 open-label study with long-term follow-up.

2025-05-04

S229: PROPHYLACTIC EFFICACY OF INTRATHECAL VERSUS INTRAVENOUS METHOTREXATE FOR CNS RELAPSE IN HIGH-RISK DIFFUSE LARGE B CELL LYMPHOMA: A PHASE III RANDOMIZED, CONTROLLED STUDY

HemaSphere2023-08-016 citations

A pilot study to determine the timing and effect of bevacizumab on vascular normalization of metastatic brain tumors in breast cancer.

2016-07-1317 citations

A pilot study of bevacizumab combined with etoposide and cisplatin in breast cancer patients with leptomeningeal carcinomatosis.

2015-04-1751 citations

Abstract 2984: Normalization of tumor vasculature by anti-angiogenesis therapy in metastatic tumor: A clinical study to determine the timing and effect

Cancer Research2014-10-013 citations

Abstract P2-16-02: Bevacizumab, etoposide, and cisplatin (BEEP) is highly effective in brain metastases of HER2 positive breast cancer progressing from whole brain radiotherapy - Subgroup analysis of a multi-center phase II study

Cancer Research2013-12-151 citations