Hypofractionation

RADIATION16 trials

Sponsors

Proton Medical Research Center, University of Tsukuba, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Sir Mortimer B. Davis - Jewish General Hospital, University Hospital, Ghent, Post Graduate Institute of Medical Education and Research, Chandigarh

Conditions

Breast CancerBreast NeoplasmsEndometrial CancerLocally Advanced Cervical CarcinomaLocally Advanced Esophageal or GE Junction CancerLymph Node MetastasesProstate CancerProstate cancer

Phase 1

HYpofractionated Pelvic Radiotherapy for Advanced Cervical Cancers INeligible for ChemoTherapy

Not yet recruitingNCT05210270

University of Santo Tomas Hospital, PhilippinesLocally Advanced Cervical Carcinoma

Start: 2024-01-31End: 2030-03-31Target: 55Updated: 2023-01-31

Phase 2

Hypofractionated Adaptive Image-Guided Radiation Therapy for Localized Adenocarcinoma of the Prostate

CompletedNCT00809991

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsProstate Cancer

Start: 2008-12-22End: 2025-09-01Updated: 2026-02-18

Hypofractionated Radiotherapy as Primary Therapy for Prostate Cancer

CompletedNCT01921803

University Hospital, GhentProstate Cancer

Start: 2013-08-01End: 2020-07-14Updated: 2022-12-22

Hypofractionated Radiotherapy for Prostate Cancer

CompletedNCT02311049

University Hospital, GhentProstate Cancer

Start: 2013-06-01End: 2020-06-14Updated: 2022-12-29

Phase II study of hypofractionated proton beam therapy for localized prostate cancer

Active, not recruitingJPRN-UMIN000017679

Proton Medical Research Center, University of TsukubaProstate cancer

Start: 2015-07-01Target: 120Updated: 2026-06-29

2-weeks of Adjuvant Radiotherapy in Patients With Breast Cancer

CompletedNCT02460744

Post Graduate Institute of Medical Education and Research, ChandigarhBreast Cancer

Start: 2013-06-30End: 2014-10-31Updated: 2015-06-02

A Trial of 15 Fraction vs 25 Fraction Pencil Beam Scanning Proton Radiotherapy After Mastectomy in Patients Requiring Regional Nodal Irradiation

CompletedNCT02783690

Mayo ClinicBreast Cancer

Start: 2016-05-18End: 2023-11-18Updated: 2025-12-04

Hypofractionated Definitive Chemoradiotherapy for Oesophageal Cancer

RecruitingNCT07632079

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Locally Advanced Esophageal or GE Junction Cancer

Start: 2026-04-28End: 2028-07-01Target: 60Updated: 2026-06-08

Phase 3

Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate

Active, not recruitingNCT01444820

Sir Mortimer B. Davis - Jewish General HospitalProstate Cancer

Start: 2012-01-31End: 2026-01-31Updated: 2024-12-04

Hypo Versus Conventional Fractionation in Reconstructed-Breast Cancer Mastectomy Patients

Not yet recruitingNCT05253170

Seoul National University Bundang HospitalBreast Cancer, Radiotherapy; Complications

Start: 2022-04-01End: 2032-12-31Target: 622Updated: 2022-03-11

Unknown Phase

Whole Breast + Lymph Node Irradiation: Prone Compared to Supine Position in 15 or 5 Fractions

CompletedNCT03280719

University Hospital, GhentBreast Neoplasms, Lymph Node Metastases, Radiotherapy

Start: 2017-09-15End: 2021-06-09Updated: 2024-09-19

Hypofractionation And Ultra-Hypofractionation In Adjuvant Radiotherapy For Breast Cancer

Alexandria UniversityBreast Cancer

Start: 2019-06-28End: 2021-06-28Target: 100Updated: 2021-04-01

Pre-operative RadiothErapy for Soft Tissue SarcOmas

Active, not recruitingNCT04617327

McGill University Health Centre/Research Institute of the McGill University Health CentreSoft Tissue Sarcoma Adult

Start: 2020-06-05End: 2027-12-31Target: 15Updated: 2025-06-25

Stereotactic Pelvic Adjuvant Radiation Therapy in Cancers of the Uterus II

Sunnybrook Health Sciences CentreEndometrial Cancer

Start: 2021-07-15End: 2023-06-01Target: 50Updated: 2021-10-25

Hypofractionated Radiotherapy in Breast Cancer Patients With Prosthetic Reconstruction

RecruitingNCT05491395

Barretos Cancer HospitalBreast Cancer

Start: 2022-06-27End: 2029-05-01Target: 120Updated: 2022-08-08

Pre-operative Hypofractionated Proton Therapy

RecruitingNCT05917301

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsSoft Tissue Sarcoma

Start: 2024-04-18End: 2032-12-01Target: 40Updated: 2026-04-17

Related Papers

Prospective phase II trial of preoperative hypofractionated proton therapy for extremity and truncal soft tissue sarcoma: the PRONTO study rationale and design

Radiation Oncology2024-05-143 citations

Conventional versus hypofractionated postmastectomy proton radiotherapy in the USA (MC1631): a randomised phase 2 trial.

2023-09-0821 citations

Feasibility of hypofractionated pelvic radiotherapy with parametrial and nodal simultaneous integrated boost for locally advanced cervical cancers: dummy run for the HYACINCT trial

Asian Journal of Oncology2023-07-14

2022 Year in Review

Oncology Times2022-12-20

Phase 1/2 trial evaluating the effectiveness and safety of dose-adapted Hypofractionated pelvic radiotherapy for Advanced Cervical cancers INeligible for ChemoTherapy (HYACINCT)

Acta Oncologica2022-03-1412 citations

Breast cancer hypofractionated radiotherapy in 2-weeks with 2D technique: 5-year clinical outcomes of a phase 2 trial.

2021-08-127 citations

Hypofractionated, dose escalation radiotherapy for high-risk prostate cancer: The primary endpoint of a group led phase III trial. (PCS5).

Journal of Clinical Oncology2018-02-206 citations

4 Weeks Versus 5 Weeks of Hypofractionated High-dose Radiation Therapy as Primary Therapy for Prostate Cancer: Interim Safety Analysis of a Randomized Phase 3 Trial.

2017-12-196 citations

A Phase 2 Study of 2 Weeks of Adjuvant Whole Breast/Chest Wall and/or Regional Nodal Radiation Therapy for Patients With Breast Cancer.

2017-12-1615 citations