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Hyperglycemic clamp

DIAGNOSTIC_TEST12 trials

Sponsors

Vanderbilt University, National Institute on Aging (NIA), Oslo University Hospital, Diabeteszentrum Bad Lauterberg im Harz, VA Office of Research and Development

Conditions

Diabetes MellitusDysglycemiaFibrous DysplasiaHealthy Adult ParticipantsHealthy VolunteersHyperglycemiaIGT - Impaired Glucose ToleranceImpaired Glucose Tolerance

Phase 1

The Role of Endocannabinoids in Insulin Production and Action
CompletedNCT01517100
National Institute on Aging (NIA)Healthy Volunteers
Start: 2012-01-05End: 2014-10-06Updated: 2026-09-08
The Reduced Insulinotropic Effect of a Continuous Infusion Relative to a Bolus Injection of GIP
CompletedNCT02673554
Diabeteszentrum Bad Lauterberg im HarzType 2 Diabetes
Start: 2004-05-31Updated: 2016-02-04
Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp
WithdrawnNCT05456854
Massachusetts General HospitalMetabolic Disease
Start: 2022-06-03End: 2024-08-01Updated: 2024-08-14
Alpelisib Challenge Test (ACT)
RecruitingNCT07778524
Columbia UniversityHealthy Adult Participants, Insulin Resistance, Obesity & Overweight +1
Start: 2026-09-02End: 2028-08-31Target: 15Updated: 2026-09-03

Phase 2

The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction
RecruitingNCT05499702
Adrian VellaType2diabetes
Start: 2022-12-15End: 2027-12-31Target: 20Updated: 2026-05-28

Phase 4

Renin-Angiotensin and Fibrinolysis in Humans: Effect of Long-Term PDE5 Inhibition on Glucose Homeostasis
TerminatedNCT01409993
Vanderbilt UniversityImpaired Glucose Tolerance
Start: 2011-08-31End: 2016-11-30Updated: 2017-04-17
Regulation of Insulin Secretion by the GLP-1 Receptor
TerminatedNCT02844907
VA Office of Research and DevelopmentInsulin Secretion
Start: 2018-07-01End: 2021-12-31Updated: 2024-12-12

Unknown Phase

GLP-1 Effects on Insulin and Glucagon in PTDM
CompletedNCT02591849
Oslo University HospitalPost-transplant Diabetes Mellitus
Start: 2014-10-31End: 2015-03-31Updated: 2016-03-31
Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes
CompletedNCT03195400
Yale UniversityIGT - Impaired Glucose Tolerance, T2D
Start: 2017-03-01End: 2022-08-12Updated: 2023-02-23
Type 2 Diabetes and the Brain in Adolescents
CompletedNCT03461510
Nemours Children's ClinicDysglycemia, Hyperglycemia, Insulin Resistance +3
Start: 2017-12-05End: 2019-01-30Updated: 2019-09-09
Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome
WithdrawnNCT03520153
Yale UniversityDiabetes Mellitus, Fibrous Dysplasia, Intraductal Papillary Mucinous Neoplasm +1
Start: 2018-08-07End: 2021-08-31Updated: 2019-09-04
Using Wearable Sensors To Understand Low Blood Sugar in Type 1 Diabetes
Not yet recruitingNCT06727071
University of California, San DiegoType 1 Diabetes Mellitus
Start: 2025-02-01End: 2026-06-30Target: 20Updated: 2024-12-10