Hyaluronidase

DRUG17 trials

Sponsors

National Heart, Lung, and Blood Institute (NHLBI), Amphastar Pharmaceuticals, Inc., Mauricio Jose Tornelli, Northwestern University, Yale University

Conditions

Addition of Hyalase to Local Anesthetic in Scalp BlockAllergic Skin ReactionCardiac ArrhythmiasCardiovascular DiseasesCoronary DiseaseDiffuse Large B-cell LymphomaDrug SafetyHealthy

Early Phase 1

Reducing and Removing Hyaluronic Acid Filler With Hyaluronidase

Active, not recruitingNCT01722916

Northwestern UniversityDrug Safety

Start: 2012-10-31End: 2025-12-31Target: 5Updated: 2025-01-31

Acceleration of Insulin Action by Hyaluronidase During Closed-Loop Therapy

CompletedNCT01945099

Yale UniversityType 1 Diabetes

Start: 2013-09-30End: 2016-07-31Updated: 2022-05-24

Safety and Efficacy of Addition of Hyaluronidase to Lidocaine and Bupivacaine in Scalp Nerves Block in Elective Craniotomy Operations, Comparative Study

CompletedNCT03411330

Cairo UniversityAddition of Hyalase to Local Anesthetic in Scalp Block

Start: 2017-01-24End: 2018-04-24Updated: 2018-04-27

Hyaluronidase Via LADD Scleroderma-induced Microstomia

CompletedNCT05995626

University of NebraskaMicrostomia, Scleroderma

Start: 2024-03-01End: 2024-09-24Updated: 2025-04-13

Effect of Hyaluronidase in Different Doses Added to Bupivacaine on TAB Block Quality During CS

Not yet recruitingNCT06839391

Benha UniversityTab Block Qaulity

Start: 2025-03-31End: 2026-04-30Target: 120Updated: 2025-02-21

Phase 1

Hyaluronidase Effect on Infusion Set Life

CompletedNCT02199028

Stanford UniversityType 1 Diabetes Mellitus

Start: 2014-07-31End: 2015-03-31Updated: 2019-10-11

Phase 2

Evaluation of the Allergenicity of AMPHADASE INJECTION (Hyaluronidase Injection USP)

CompletedNCT01689363

Amphastar Pharmaceuticals, Inc.Allergic Skin Reaction

Start: 2012-09-30End: 2012-12-31Updated: 2017-01-20

Peripheral Modulation of Muscle Stiffness and Spasticity

Active, not recruitingNCT03306615

Johns Hopkins UniversityMuscle Spasticity

Start: 2021-10-11End: 2026-06-30Target: 56Updated: 2026-03-09

Effectiveness of Adding Hyaluronidase to Bupivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block

Sohag UniversityPostoperative Pain

Start: 2021-09-10End: 2021-12-31Target: 40Updated: 2021-10-27

Polatuzumab Vedotin With R-GDP in Relapsed/Refractory Diffuse Large B-cell Lymphoma

Active, not recruitingNCT05498220

UNC Lineberger Comprehensive Cancer CenterDiffuse Large B-cell Lymphoma

Start: 2023-02-17End: 2026-11-07Updated: 2025-09-02

Phase 3

Multicenter Investigation of Limitation of Infarct Size (MILIS)

CompletedNCT00000493

National Heart, Lung, and Blood Institute (NHLBI)Cardiovascular Diseases, Coronary Disease, Heart Diseases +2

Start: 1977-09-30End: 1985-12-31Updated: 2016-07-12

Hyaluronidase Assisted Subcutaneous Infusion

CompletedNCT06604546

Shanghai Bao Pharmaceuticals Co., Ltd.Healthy

Start: 2024-03-28End: 2024-08-10Updated: 2024-09-23

Phase 4

Hemodynamic and Electrocardiographic Effects of Hyaluronidase Associated With Local Anaesthetics

CompletedNCT01719978

Mauricio Jose TornelliCardiac Arrhythmias

Start: 2007-10-31End: 2011-12-31Updated: 2012-11-02

Unknown Phase

Use of Recombinant Hyaluronidase Human is Effective for the Use of Local Blocks for Eyelid's Surgery

WithdrawnNCT02059694

Duke UniversityUpper Eyelid Surgery

Updated: 2014-12-19

Effect of Hyaluronidase on Intraocular Pressure

Assiut UniversityIntraocular Pressure Low

Start: 2017-09-30End: 2018-10-31Target: 50Updated: 2017-08-30

Ultrasound Guided Erector Spinae Plane Block in Breast Surgery

Assiut UniversityPostoperative Pain

Start: 2018-05-19End: 2020-12-31Target: 60Updated: 2020-04-09

Effect of Adding Hyaluronidase to Bupivacaine in Transversus Abdominis Plane Block for Cesarean Section

CompletedNCT05671172

Benha UniversityPain, Postoperative

Start: 2023-05-15End: 2024-02-10Updated: 2025-09-19

Related Papers

Effectiveness of Low Doses of Hyaluronidase to Remove Hyaluronic Acid Filler Nodules

JAMA Dermatology2018-04-2528 citations