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Histotripsy

DEVICE6 trials

Sponsors

Memorial Sloan Kettering Cancer Center, The University of Hong Kong, National Taiwan University Hospital, Northwell Health, University of Wisconsin, Madison

Conditions

Abdominal TumorsBreast CancerBreast Cancer Stage IVColorectal (Colon or Rectal) CancerIntrahepatic CholangiocarcinomaLiver TumorsLiver TumourLocally Advanced Breast Cancer

Phase 1

A Study of Pembrolizumab and Ablation (Cryoablation or Histotripsy) in People With Breast Cancer
RecruitingNCT06246968
Memorial Sloan Kettering Cancer CenterBreast Cancer, Breast Cancer Stage IV, Locally Advanced Breast Cancer +5
Start: 2024-01-29End: 2027-01-29Target: 30Updated: 2026-09-14
Evaluation of Circulating Immune Response After Histosonics in Colorectal Cancer (ECHO-CRC)
RecruitingNCT07361107
Northwell HealthColorectal (Colon or Rectal) Cancer
Start: 2025-09-26End: 2027-09-27Target: 12Updated: 2026-01-22

Phase 2

Combination Therapy Using Durvalumab and Histotripsy for Treatment of Intrahepatic Cholangiocarcinoma
Not yet recruitingNCT07766187
University of Wisconsin, MadisonIntrahepatic Cholangiocarcinoma
Start: 2026-09-01End: 2032-08-01Target: 12Updated: 2026-09-02

Unknown Phase

Histotripsy (HistoSonics®) for Liver Tumours
Active, not recruitingNCT06579833
The University of Hong KongLiver Tumour
Start: 2024-08-29End: 2028-09-01Target: 60Updated: 2025-12-16
Safety and Clinical Efficacy of Histotripsy for Liver Cancers Adjacent to Major Intrahepatic Vessels
Not yet recruitingNCT07063771
National Taiwan University HospitalLiver Tumors
Start: 2025-08-01End: 2027-07-31Target: 20Updated: 2025-07-14
To Evaluate the Safety and Efficacy of Histotripsy for the Symptom Relief of Inoperable Abdominal Tumors
Not yet recruitingNCT07180706
National Taiwan University HospitalAbdominal Tumors
Start: 2025-10-01End: 2027-07-31Target: 30Updated: 2025-09-18