Gantenerumab
Sponsors
Hoffmann-La Roche, Chugai Pharmaceutical, Washington University School of Medicine
Conditions
Alzheimer DiseaseAlzheimer's DiseaseAlzheimers DiseaseAlzheimers Disease, FamilialDementiaHealthy ParticipantsHealthy Volunteer
Phase 1
A Multiple Ascending Dose Study of R1450 in Patients With Alzheimer Disease.
CompletedNCT00531804
Start: 2006-12-31End: 2010-09-30Updated: 2016-11-02
A Study of A High Concentration Liquid Formulation Versus A Lyophilized Formulation of Gantenerumab in Healthy Volunteers
CompletedNCT01636531
Start: 2012-05-31End: 2012-10-31Updated: 2016-11-02
A Multiple-dose Study of Gantenerumab in Japanese Alzheimer&Apos;s Disease Patients
CompletedNCT01656525
Start: 2012-06-30End: 2014-06-30Updated: 2014-09-19
A Study Investigating the Bioavailability of a High Concentration Liquid Formulation Versus a Reference Lyophilized Formulation of Gantenerumab in Healthy Volunteers
CompletedNCT02133937
Start: 2014-04-30End: 2014-09-30Updated: 2016-11-02
A Single-Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics (PK) of Gantenerumab Following Subcutaneous (SC) Administration in Healthy Volunteers
CompletedNCT02711423
Start: 2016-03-31End: 2016-09-28Updated: 2019-04-10
A Study to Assess the Impact of Speed and Site of Subcutaneous Injection on Pain, Tolerability, Safety, and Pharmacokinetics of Gantenerumab in Healthy Participants
CompletedNCT02882009
Start: 2016-08-31End: 2017-03-22Target: 48Updated: 2019-06-11
Relative Bioavailability of Gantenerumab Produced by G4 Process Versus G3 Process Following Subcutaneous (SC) Injection in Healthy Participants
CompletedNCT03236844
Start: 2017-08-01End: 2017-12-15Updated: 2018-12-12
Phase 2
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001
Active, not recruitingNCT01760005
Start: 2012-12-01End: 2028-07-01Target: 490Updated: 2026-02-13
A Study to Evaluate the Pharmacodynamic (PD) Effects of Once Weekly Administration of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
TerminatedNCT04592341
Start: 2020-11-18End: 2023-03-15Updated: 2024-03-27
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation.
CompletedNCT04623242
Start: 2012-12-31End: 2020-03-06Updated: 2022-09-22
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation
TerminatedNCT06424236
Start: 2020-06-03End: 2023-11-13Updated: 2025-02-04
Phase 3
A Study of Gantenerumab in Participants With Prodromal Alzheimer's Disease
CompletedNCT01224106
Start: 2010-11-30End: 2020-09-10Updated: 2021-12-13
A Study of Gantenerumab in Participants With Mild Alzheimer Disease
CompletedNCT02051608
Start: 2014-03-27End: 2021-04-16Updated: 2023-02-10
Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
TerminatedNCT03443973
Start: 2018-08-22End: 2022-11-28Updated: 2024-01-17
Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
TerminatedNCT03444870
Start: 2018-06-06End: 2023-02-17Updated: 2024-01-30
A Study to Evaluate the Safety and Tolerability of Long-term Administration of Gantenerumab in Participants With Alzheimer's Disease (AD)
TerminatedNCT04339413
Start: 2020-05-22End: 2023-01-04Updated: 2024-01-18
A Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Participants With Alzheimer's Disease (AD)
TerminatedNCT04374253
Start: 2021-01-26End: 2023-03-06Updated: 2024-05-08
A Study to Evaluate the Efficacy and Safety of Gantenerumab in Participants at Risk for or at the Earliest Stages of Alzheimer's Disease (AD)
TerminatedNCT05256134
Start: 2022-04-19End: 2023-03-13Updated: 2025-06-12
Related Papers
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