ExoFlo

BIOLOGICAL8 trials

Sponsors

Direct Biologics, LLC

Conditions

ARDSAcute Respiratory Distress SyndromeCOVID-19Covid19Crohn DiseaseCrohn's DiseaseCytokine StormHypoxia

Phase 1

Study of ExoFlo for the Treatment of Medically Refractory Crohn's Disease

TerminatedNCT05130983

Direct Biologics, LLCCrohn Disease, Inflammatory Bowel Diseases

Start: 2023-01-23End: 2024-12-01Updated: 2025-02-11

Study of ExoFlo for the Treatment of Medically Refractory Ulcerative Colitis

TerminatedNCT05176366

Direct Biologics, LLCInflammatory Bowel Diseases, Ulcerative Colitis

Start: 2022-12-19End: 2024-12-01Updated: 2025-02-11

Study of ExoFlo for the Treatment of Perianal Fistulas

TerminatedNCT05836883

Direct Biologics, LLCCrohn's Disease, Perianal Fistula

Start: 2023-08-28End: 2024-12-01Updated: 2025-02-11

Phase 2

Extracellular Vesicle Infusion Treatment for COVID-19 Associated ARDS

CompletedNCT04493242

Direct Biologics, LLCARDS, COVID-19

Start: 2020-09-24End: 2021-05-22Updated: 2024-02-13

Extracellular Vesicles Infusion Treatment for Mild-to-Moderate COVID-19

WithdrawnNCT05125562

Direct Biologics, LLCCOVID-19

Start: 2022-12-07End: 2023-03-07Updated: 2024-02-13

Phase 3

Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)

RecruitingNCT05354141

Direct Biologics, LLCAcute Respiratory Distress Syndrome, ARDS

Start: 2022-07-01End: 2027-12-31Target: 970Updated: 2026-02-23

Unknown Phase

Expanded Access for Use of bmMSC-Derived Extracellular Vesicles in Patients With COVID-19 Associated ARDS

Direct Biologics, LLCARDS, Covid19, Cytokine Storm +1

Updated: 2024-11-22

Expanded Access for Use of ExoFlo in Abdominal Solid Organ Transplant Patients

Direct Biologics, LLCOrgan Rejection, Organ Rejection Transplants, Solid Organ Transplant Rejection

Updated: 2024-07-29

Related Papers

Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicle Infusion for the Treatment of Respiratory Failure From COVID-19: A Randomized, Placebo-Controlled Dosing Clinical Trial.

2023-06-2390 citations