Ertugliflozin
Sponsors
Eli Lilly Cork Limited, Merck Sharp & Dohme LLC, Eli Lilly & Co., Universita Cattolica Del Sacro Cuore, University Health Network, Toronto
Conditions
AtherosclerosisCardiovascular DiseasesChronic Kidney diseaseCongestionDiabetes Mellitus, Type 2Healthy VolunteerHeart FailureHeart Failure With Nonischemic Cardiomyopathy
Early Phase 1
Phase 1
A Single Escalating Dose Study Of Ertugliflozin (PF-04971729, MK-8835) Under Fed and Fasted Conditons In Healthy Volunteers (MK-8835-036)
CompletedNCT00989079
Start: 2009-10-16End: 2009-12-11Updated: 2020-05-29
A Multiple Dose Study Of Ertugliflozin (PF-04971729, MK-8835) In Otherwise Healthy Overweight And Obese Volunteers (MK-8835-037)
CompletedNCT01018823
Start: 2009-12-14End: 2010-03-18Updated: 2020-05-29
A Radiolabeled Mass Balance Study of [14C]-Ertugliflozin (PF04971729, MK-8835) In Healthy Male Participants (MK-8835-038)
CompletedNCT01127308
Start: 2010-06-30End: 2010-07-31Updated: 2016-03-23
Evaluation of Pharmacokinetics, Safety, And Tolerability Of Ertugliflozin (PF-04971729, MK-8835) In Japanese And Western Healthy Participants (MK-8835-041)
CompletedNCT01223339
Start: 2010-10-31End: 2011-02-28Updated: 2016-05-20
Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Ertugliflozin in Participants With Type 2 Diabetes Mellitus (MK-8835-009)
CompletedNCT01948986
Start: 2013-10-01End: 2014-10-16Updated: 2019-02-18
Phase 2
ERtugliflozin triAl in DIabetes With Preserved or Reduced ejeCtion FrAcTion mEchanistic Evaluation in Heart Failure
CompletedNCT03416270
Start: 2018-06-28End: 2021-04-14Updated: 2025-05-06
Ertugliflozin in Chronic Heart Failure
RecruitingNCT04438213
Start: 2021-03-10End: 2025-12-30Target: 60Updated: 2025-10-08
Phase 3
Cardiovascular Outcomes Following Ertugliflozin Treatment in Type 2 Diabetes Mellitus Participants With Vascular Disease, The VERTIS CV Study (MK-8835-004)
CompletedNCT01986881
Start: 2013-11-04End: 2019-12-27Updated: 2022-09-23
Efficacy and Safety of Ertugliflozin (MK-8835/PF-04971729) With Sitagliptin in the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Diet and Exercise (MK-8835-017)
CompletedNCT02226003
Start: 2014-09-23End: 2016-02-23Updated: 2018-09-13
Effect of Ertugliflozin on Cardiac Function in Diabetes
CompletedNCT03717194
Start: 2019-06-01End: 2023-04-30Updated: 2024-11-20
Ertugliflozin for Functional Mitral Regurgitation
CompletedNCT04231331
Start: 2020-11-04End: 2023-11-15Updated: 2025-01-06
Validation of ERTugliflozin for Inhibiting Cardiac Fibrosis Using Cardiac MRI and Laboratory Parameters in Korean Heart Failure Patients With Nonischemic Cardiomyopathy(VERTICAL)
NCT04490681
Start: 2020-08-31End: 2022-12-31Target: 52Updated: 2020-08-07
A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled Clinical Study to Evaluate the Safety and Efficacy of Ertugliflozin (MK-8835/PF-04971729) in Pediatric Participants (ages 10 to 17 years, inclusive) with Type 2 Diabetes Mellitus (MK-8835-059/B1521066)
CompletedCTIS2022-501085-21-00
Start: 2019-11-29End: 2024-11-19Target: 20Updated: 2024-09-09
J2A-MC-GZGS: A Phase 3, Open-Label Study of Once Daily Orforglipron Compared with Insulin Glargine in Adult Participants with Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk (ACHIEVE-4)
Active, not recruitingCTIS2022-502833-25-00
Start: 2023-08-02Target: 1040Updated: 2025-11-26
Phase 4
Ertugliflozin Versus Hydrochlorothiazide in Reducing Sympathetic Neural Overactivity in Patients With Hypertension and Recently-diagnosed Type 2 Diabetes.
WithdrawnNCT03640221
Start: 2018-09-01End: 2020-08-31Updated: 2020-01-14
ERTU-SODIUM: Study on the Effects of Ertugliflozin on Sodium Storage, Interstitial Volume, and Plasma Volume in HFrEF
NCT05152940
Start: 2023-03-20End: 2024-12-31Target: 28Updated: 2023-10-13
A Phase 4, Randomized, Open-Label, Active-Controlled Study to Investigate the Efficacy and Safety of Switching From Weekly Dulaglutide to Weekly Tirzepatide in Adults With Type 2 Diabetes
CompletedCTIS2022-500101-41-00
Start: 2023-06-07End: 2024-07-23Target: 145Updated: 2024-08-05
SGLT-2i, Heart, Improvement of Cardiovascular Autonomic Neuropathy
RecruitingCTIS2025-521748-39-00
Start: 2025-11-14Target: 80Updated: 2025-12-09
Related Papers
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