Entacapone

DRUG16 trials

Sponsors

Rambam Health Care Campus, Novartis, Satish R. Raj, Assistance Publique - Hôpitaux de Paris, National Institute of Neurological Disorders and Stroke (NINDS)

Conditions

Autonomic Nervous System DiseasesChronic Orthostatic IntoleranceGastrointestinal Stromal Tumor, MalignantHealthyMethamphetamine DependenceMultiple System AtrophyObesityParkinson Disease

Early Phase 1

Pilot Study of Entacapone for Methamphetamine Abuse

CompletedNCT02058966

Oregon Health and Science UniversityMethamphetamine Dependence

Start: 2014-06-30End: 2016-06-30Updated: 2019-09-12

Entacapone Combination With Imatinib for Treatment of GIST

CompletedNCT04006769

Xiangya Hospital of Central South UniversityGastrointestinal Stromal Tumor, Malignant

Start: 2020-10-30End: 2022-08-31Updated: 2023-10-18

Phase 1

Treatment of Orthostatic Intolerance

Active, not recruitingNCT00262470

Satish R. RajChronic Orthostatic Intolerance, Tachycardia

Start: 1997-04-30End: 2029-12-31Target: 150Updated: 2025-10-08

Augmenting Effects of L-DOPS With Carbidopa and Entacapone

TerminatedNCT00547911

National Institute of Neurological Disorders and Stroke (NINDS)Autonomic Nervous System Diseases, Multiple System Atrophy, Parkinson Disease

Start: 2007-10-31End: 2013-04-30Updated: 2014-07-17

Study of BIA 9-1067 to Investigate Its Effect on Levodopa Pharmacokinetic

CompletedNCT01519284

Bial - Portela C S.A.Parkinson Disease

Start: 2009-11-30End: 2011-06-30Updated: 2015-08-20

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ODM-103 in Healthy Volunteers

CompletedNCT01688089

Orion Corporation, Orion PharmaHealthy

Start: 2012-09-30End: 2014-09-30Updated: 2014-09-19

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ODM-104 in Healthy Volunteers

CompletedNCT01840423

Orion Corporation, Orion PharmaHealthy

Start: 2013-05-31End: 2014-12-31Updated: 2015-04-01

A Safety, Tolerability, and Pharmacokinetic Study of ND0612 Delivered as a Continuous Subcutaneous in Parkinson's Disease Patients

CompletedNCT02096601

NeuroDerm Ltd.Parkinson's Disease

Start: 2014-08-11End: 2015-03-15Updated: 2024-04-29

The Effect of BIA 9-1067 at Steady-state on the Levodopa Pharmacokinetics

CompletedNCT02170376

Bial - Portela C S.A.Parkinson's Disease (PD)

Start: 2011-09-30End: 2012-01-31Updated: 2016-09-20

Effect of Entacapone on Bodyweight Loss in Obese Population

Kaichun WuObesity

Start: 2015-01-31End: 2015-11-30Target: 30Updated: 2015-02-02

Phase 2

An Extension Study of Entacapone in Patients With Parkinson's Disease With End-of-dose Wearing-off. This Study is Not Recruiting in the United States

CompletedNCT00237263

NovartisParkinson's Disease

Start: 2003-02-28End: 2007-07-31Updated: 2024-01-11

Phase 3

Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients With Wearing-off Phenomenon

CompletedNCT01568073

Bial - Portela C S.A.Parkinson's Disease

Start: 2011-03-31End: 2013-11-30Updated: 2015-09-18

Phase 4

COMT Polymorphism and Entacapone Efficacy

CompletedNCT00373087

Assistance Publique - Hôpitaux de ParisParkinson's Disease

Start: 2006-10-31End: 2009-11-30Updated: 2010-04-29

Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors

CompletedNCT00906828

Uppsala UniversityParkinson Disease

Start: 2008-10-31End: 2009-11-30Target: 10Updated: 2010-01-18

Unknown Phase

Entacapone Augmentation for Schizophrenia

CompletedNCT00192855

Rambam Health Care CampusSchizophrenia

Start: 2003-06-30End: 2006-10-31Updated: 2010-08-25

Impact of H1 Forel's field deep brain stimulation on Parkinson's disease gait disorders

Active, not recruitingRBR-9msccy

Hospital Santa MarcelinaParkinson's disease

Start: 2015-02-03Updated: 2025-10-27

Related Papers

The Cost-Effectiveness of Opicapone Versus Entacapone as Adjuvant Therapy for Levodopa-Treated Individuals With Parkinson's Disease Experiencing End-of-Dose Motor Fluctuations.

2025-09-11

Splanchnic Venous Compression Enhances the Effects of ß-Blockade in the Treatment of Postural Tachycardia Syndrome.

2020-07-1613 citations

Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial.

2015-12-23158 citations

Postural Tachycardia Syndrome and Inappropriate Sinus Tachycardia: Role of Autonomic Modulation and Sinus Node Automaticity

Journal of the American Heart Association2014-03-2453 citations