Enbrel 25 mg powder and solvent for solution for injection

DRUG4 trials

Sponsors

Janssen - Cilag International, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Narodowy Instytut Geriatrii Reumatologii I Rehabilitacji Im Prof. Dr Hab. Med. Eleonory Reicher, Sint Maartenskliniek Stichting

Conditions

Chronic Plaque PsoriasisJuvenile Idiopathic ArthritisRheumatoid arthritisSAPHO syndrome (synovitisacnehyperostosislimiting the daily activity of patients. About half of patients present also with symptoms of severe axial spondyloarthritis. It can also lead to local bone destruction (usually sternoclavicular joints).osteitis) is a rare disease in which arthritis and osteitis is accompanied by skin lesions such as pustular psoriasis or acne. SAPHO syndrome significantly reduces the quality of life of patients due to the chronic occurrence of pain

Phase 2

A multicenter, randomized, double-blind clinical trial evaluating the efficacy and safety of etanercept versus placebo in the treatment of patients with SAPHO syndrome

RecruitingCTIS2024-516919-25-00

Narodowy Instytut Geriatrii Reumatologii I Rehabilitacji Im Prof. Dr Hab. Med. Eleonory Reicheracne, hyperostosis, limiting the daily activity of patients. About half of patients present also with symptoms of severe axial spondyloarthritis. It can also lead to local bone destruction (usually sternoclavicular joints). +3

Start: 2024-10-22Target: 60Updated: 2024-10-31

Phase 3

A Phase 3, Multicenter, Randomized, Placebo- and Active Comparator-Controlled Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Guselkumab for the Treatment of Chronic Plaque Psoriasis in Pediatric Participants (≥6 To <18 Years of Age)

Active, not recruitingCTIS2023-503378-19-00

Janssen - Cilag InternationalChronic Plaque Psoriasis

Start: 2018-08-23Target: 97Updated: 2026-01-15

Phase 4

A randomized, two-armed, single-blind, parallel, active controlled, and non-inferiority clinical trial to Compare Efficacy and Safety of anti TNF-alfa biosimilar molecules to the originators in children with active Juvenile Idiopathic Arthritis

RecruitingCTIS2024-515557-22-00

Fondazione IRCCS Ca Granda Ospedale Maggiore PoliclinicoJuvenile Idiopathic Arthritis

Start: 2022-10-01Target: 290Updated: 2025-04-17

DISCO-RA:DIScontinuation of COncomitant disease modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis patients also using TNF inhibitors - a randomized long-term non-inferiority strategy trial

Not yet recruitingCTIS2026-525316-33-00

Sint Maartenskliniek StichtingRheumatoid arthritis

Target: 202Updated: 2026-06-09