Empliciti 400 mg powder for concentrate for solution for infusion.
Sponsors
Regeneron Pharmaceuticals Inc., Janssen - Cilag International, Celgene Corp., Pfizer Inc., Celgene International II S.a.r.l.
Conditions
Multiple MyelomaNewly Diagnosed Multiple MyelomaRelapsed Refractory Multiple MyelomaRelapsed and/or
Refractory Multiple MyelomaRelapsed or Refractory Multiple Myeloma (RRMM)Relapsed or Refractory MyelomaRelapsed or refractory multiple myeloma (RRMM) and newly diagnosed MM (NDMM)Relapsed/Refractory Multiple Myeloma
Phase 1
Phase 2
Phase 3
AN OPEN-LABEL, RANDOMIZED, PHASE 3 STUDY OF LINVOSELTAMAB (REGN5458; ANTI-BCMA X ANTI-CD3 BISPECIFIC ANTIBODY) VERSUS THE COMBINATION OF ELOTUZUMAB, POMALIDOMIDE, AND DEXAMETHASONE (EPd), IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (LINKER-MM3)
Active, not recruitingCTIS2022-501396-62-00
Start: 2023-12-12Target: 188Updated: 2025-10-26
A Phase 3 Randomized Study Comparing Talquetamab in Combination with Pomalidomide (Tal-P), Talquetamab in Combination with Teclistamab (Tal-Tec), and Investigator’s Choice of Either Elotuzumab, Pomalidomide, and Dexamethasone (EPd) or Pomalidomide, Bortezomib, and Dexamethasone (PVd) in Participants with Relapsed or Refractory Myeloma who Have Received 1 to 4 Prior Lines of Therapy Including an Anti-CD38 Antibody and Lenalidomide
Active, not recruitingCTIS2022-502446-27-00
Start: 2024-02-26Target: 453Updated: 2026-01-13
A Phase 3, Randomized, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of
Alnuctamab Compared to Standard of Care Regimens in Participants with Relapsed or
Refractory Multiple Myeloma (RRMM) - ALUMMINATE RRMM
CompletedCTIS2023-509472-42-00
End: 2024-05-17Target: 177Updated: 2024-04-23
C1071032 - MAGNETISMM-32 A PHASE 3, OPEN-LABEL STUDY OF ELRANATAMAB MONOTHERAPY VERSUS ELOTUZUMAB, POMALIDOMIDE, DEXAMETHASONE (EPd) OR POMALIDOMIDE, BORTEZOMIB, DEXAMETHASONE (PVd) OR CARFILZOMIB, DEXAMETHASONE (Kd) IN PARTICIPANTS WITH RELAPSED REFRACTORY MULTIPLE MYELOMA WHO RECEIVED PRIOR ANTI-CD38 DIRECTED THERAPY
RecruitingCTIS2023-507871-23-00
Start: 2024-05-27Target: 394Updated: 2026-01-27
Allogeneic stem cell transplantation vs. conventional therapy as salvage therapy for relapsed / progressive patients with multiple myeloma after a first-line therapy
CompletedCTIS2024-510590-14-00
Start: 2023-03-03End: 2025-01-30Target: 400Updated: 2025-02-05
A PHASE 3 RANDOMIZED, OPEN-LABEL TRIAL OF SELINEXOR, POMALIDOMIDE, AND DEXAMETHASONE (SPd) VERSUS ELOTUZUMAB, POMALIDOMIDE, AND DEXAMETHASONE (EloPd) IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA (RRMM)
Active, not recruitingCTIS2024-518304-53-00
Start: 2022-02-02Target: 116Updated: 2025-11-04
Elotuzumab (E) in Combination with Carfilzomib, Lenalidomide and Dexamethasone (E-KRd) versus KRd prior to and following Autologous Stem Cell Transplant in Newly Diagnosed Multiple Myeloma and Subsequent Maintenance with Elotuzumab and Lenalidomide versus Single-Agent Lenalidomide - A phase III study by DSMM (Deutsche Studiengruppe Multiples Myelom)
Active, not recruitingCTIS2024-515783-31-00
Start: 2018-08-24Target: 574Updated: 2025-12-22
HO183 CAR T: A phase III randomized trial comparing academically produced BCMA-directed CAR T-cells (ARI0002h) with standard of care regimen in patients with relapsed/refractory multiple myeloma
Not yet recruitingCTIS2025-524876-43-00
Target: 126Updated: 2026-04-29
A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Cevostamab in Combination with Pomalidomide and Dexamethasone Versus Standard of Care in Patients with Multiple Myeloma who Have Received One to Three Prior Lines of Therapy
Not yet recruitingCTIS2025-524028-23-00
Target: 43Updated: 2026-07-08