Ebselen

DRUG8 trials

Conditions

Bipolar DisorderBipolar Disorder, ManicCochlear TraumaCorona Virus InfectionCoronavirusCoronavirus InfectionCovid19Depressive Disorder, Treatment-Resistant

Phase 1

IMPase in Treatment-resistant Depression

NCT05117710

University of OxfordDepressive Disorder, Treatment-Resistant

Start: 2021-04-22End: 2024-05-31Target: 50Updated: 2023-07-06

Phase 2

Signaling Mechanisms and Vascular Function in Patients With Diabetes Mellitus

CompletedNCT00762671

Brigham and Women's HospitalType 1 Diabetes Mellitus, Type 2 Diabetes Mellitus

Start: 1999-05-31End: 2007-10-31Updated: 2008-09-30

Ebselen as an add-on Treatment in Hypo/Mania

CompletedNCT03013400

University of OxfordBipolar Disorder, Bipolar Disorder, Manic

Start: 2017-10-01End: 2019-07-09Updated: 2019-09-06

SPI-1005 Treatment in Moderate COVID-19 Patients

NCT04484025

Sound Pharmaceuticals, IncorporatedCoronavirus, Coronavirus Infection, Corona Virus Infection +1

Start: 2021-10-12End: 2023-12-31Target: 60Updated: 2023-10-03

SPI-1005 Treatment in Severe COVID-19 Patients

CompletedNCT04483973

Sound Pharmaceuticals, IncorporatedCoronavirus, Coronavirus Infection, Corona Virus Infection +1

Start: 2021-08-27End: 2023-06-06Updated: 2026-06-29

SPI-1005 in Adults Receiving Cochlear Implant

RecruitingNCT06340633

Sound Pharmaceuticals, IncorporatedCochlear Trauma, Hearing Loss

Start: 2026-12-01End: 2026-12-01Target: 40Updated: 2026-06-26

Phase 3

SPI-1005 for the Treatment of Meniere's Disease

CompletedNCT04677972

Sound Pharmaceuticals, IncorporatedMénière, Meniere Disease

Start: 2022-08-02End: 2024-07-25Updated: 2026-07-23

SPI-1005 for the Treatment of Meniere's Disease (Open Label)

Active, not recruitingNCT06859788

Sound Pharmaceuticals, IncorporatedMeniere's Disease, Ménière's Disease

Start: 2025-10-29End: 2026-12-01Target: 200Updated: 2026-07-13

Related Papers

A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania

Psychopharmacology2020-09-0960 citations

The Clinical Drug Ebselen Attenuates Inflammation and Promotes Microbiome Recovery in Mice after Antibiotic Treatment for CDI

Cell Reports Medicine2020-04-0145 citations

How many unpublished studies? ClinicalTrials.gov (n = 2614 studies): diabetes | Closed Studies | Interventional Studies | Phase 3, 4 | Search Date: Oct 27, 2014

Figshare2014-01-01