DX-2930

DRUG3 trials

Sponsors

Shire

Conditions

Hereditary Angioedema (HAE)

Phase 1

A Single Increasing Dose Study to Assess Safety and Tolerability of DX-2930 in Healthy Subjects

CompletedNCT01923207

ShireHereditary Angioedema (HAE)

Start: 2013-08-12End: 2014-01-07Updated: 2021-05-17

A Double-Blind, Multiple Ascending Dose Study to Assess Safety, Tolerability and Pharmacokinetics of DX-2930 in Hereditary Angioedema Participants

CompletedNCT02093923

ShireHereditary Angioedema (HAE)

Start: 2014-05-14End: 2015-05-18Updated: 2021-05-27

Phase 3

Long-term Safety and Efficacy Study of DX-2930 (SHP643) to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAE

CompletedNCT02741596

ShireHereditary Angioedema (HAE)

Start: 2016-05-26End: 2019-10-31Updated: 2021-06-08

Related Papers

Long-term prevention of hereditary angioedema attacks with lanadelumab in adolescents

Annals of Allergy Asthma & Immunology2024-08-106 citations

Long-term lanadelumab treatment improves health-related quality of life in patients with hereditary angioedema

Annals of Allergy Asthma & Immunology2023-04-0518 citations

Effectiveness and safety of lanadelumab in ethnic and racial minority subgroups of patients with hereditary angioedema: results from phase 3 studies

Allergy Asthma and Clinical Immunology2022-09-243 citations

Long‐term prevention of hereditary angioedema attacks with lanadelumab: The HELP OLE Study

Allergy2021-07-2191 citations

Lanadelumab for the Prophylactic Treatment of Hereditary Angioedema with C1 Inhibitor Deficiency: A Review of Preclinical and Phase I Studies.

2019-02-0116 citations

An open-label study to evaluate the long-term safety and efficacy of lanadelumab for prevention of attacks in hereditary angioedema: design of the HELP study extension

Clinical and Translational Allergy2017-10-0232 citations

Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis

New England Journal of Medicine2017-02-17167 citations

A phase 1 study investigating DX-2930 in healthy subjects

Annals of Allergy Asthma & Immunology2014-06-2657 citations