dose escalation
Sponsors
Yamaguchi University Graduate School of Medicine, Digestive surgery and surgical oncology, Jikei University School of Medicine, Cliniques universitaires Saint-Luc- Université Catholique de Louvain, University of Liverpool, Royal North Shore Hospital
Conditions
Advanced Malignant Solid TumorsAdvanced or recurrent gastric cancerDose EscalationFMISOHCC , Pancreatic cancerHIV/AIDSHead and Neck CancerHealthy Volunteers
Curcumin
Nanocurcumin
Pharmacokinetics
Safety
Phase 1
Phase I study of chemotherapy with gemcitabine, CDDP and S-1 for the patients with unresectable biliary tract cancer
Active, not recruitingJPRN-UMIN000008415
Start: 2012-07-01Target: 24Updated: 2025-07-18
A combination phase I trial of peptide vaccines and Docetaxel/5'-DFUR in patients with advanced or recurrent gastric cancer
Active, not recruitingJPRN-UMIN000009751
Start: 2007-11-01Target: 9Updated: 2025-07-18
Safety assessment and pharmacokinetics of curcumin-loaded nanocomplexes in healthy human individuals
RecruitingTCTR20191207003
Start: 2019-11-27Updated: 2026-03-30
A Study of GQ1010 in Subjects With Advanced Solid Tumors
RecruitingNCT06464055
Start: 2024-05-23End: 2028-12-31Target: 260Updated: 2025-02-10
The Safety and Efficacy of Umbilical Cord Blood Mononuclear Cells in Patients With Secondary Poor Graft Function After Hematopoietic Stem Cell Transplantation
RecruitingNCT06792682
Start: 2025-02-14End: 2028-02-29Target: 15Updated: 2025-03-13
Phase 2
Dose Escalation Study to Determine the Pharmacokinetics of Atazanavir Administered With RIfampicin to HIV Positive Adults on sEcond-line ART Regimen With Suppressed HIV-1 Viral Load
CompletedNCT04121195
Start: 2020-10-30End: 2023-05-20Updated: 2024-07-12
Multimodality- Adapted Dose Modification in Head and Neck Cancer Radiation Therapy 
NCT04933357
Start: 2019-09-16End: 2022-09-30Target: 75Updated: 2021-06-21
Unknown Phase
Phase I study of peptides derived from novel cancer antigens for advanced colorectal cancer
Active, not recruitingJPRN-UMIN000004948
Start: 2007-01-01Target: 18Updated: 2025-07-18
Phase I study of DCs therapy encoding mRNA derived from cancer antigens targeting advanced HCC & pancreatic cancer.
Active, not recruitingJPRN-UMIN000005836
Start: 2004-05-01Target: 12Updated: 2025-07-18
Molecular Imaging-based Dose Escalation in HPV Negative Patients With Locally Advanced SCC of the Oropharynx
NCT02336711
Start: 2014-11-30End: 2016-09-30Target: 10Updated: 2016-06-03
A phase 1b, open-label, multi-center, dose-escalation study of the safety, pharmacokinetics and therapeutic activity of cergutuzumab amunaleukin, an immunocytokine, which consists of a variant of interleukin-2 (IL2v) targeting carcinoembryonic antigen (CEA), and atezolizumab, an antibody that targets programmed death ligand 1 (anti-PDL1) administered intravenously, in patients with locally advanced and/or metastatic solid tumors
Active, not recruitingNL-OMON46963
Start: 2015-01-12Target: 15Updated: 2024-02-28
Advanced Techniques For Single-fraction Palliative Radiotherapy Versus Standard Multi Fraction Radiation
RecruitingNCT04649125
Start: 2021-05-31End: 2026-06-30Target: 100Updated: 2026-02-06
FMISO-based Adaptive Radiotherapy for Head and Neck Cancer
RecruitingNCT05348486
Start: 2022-04-20End: 2030-06-30Target: 120Updated: 2025-04-22