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Dapivirine Vaginal Ring

COMBINATION_PRODUCT6 trials

Sponsors

International Partnership for Microbicides, Inc., National Institute of Allergy and Infectious Diseases (NIAID)

Conditions

HIV InfectionsHuman Immunodeficiency Virus

Phase 1

Safety and Pharmacokinetics of Dapivirine/Maraviroc Vaginal Ring
CompletedNCT01363037
International Partnership for Microbicides, Inc.HIV Infections
Start: 2011-11-30End: 2012-08-31Updated: 2015-09-10
Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess the Delivery of Dapivirine From a Vaginal Ring
CompletedNCT02920827
International Partnership for Microbicides, Inc.HIV Infections
Start: 2009-08-31End: 2010-04-30Updated: 2017-09-08

Phase 2

Safety and Pharmacokinetics of Dapivirine Vaginal Ring in Post-menopausal Women
CompletedNCT02010593
International Partnership for Microbicides, Inc.Human Immunodeficiency Virus
Start: 2013-12-31End: 2015-04-30Updated: 2022-11-03
Evaluating the Safety of and Adherence to a Vaginal Matrix Ring Containing Dapivirine and Oral Emtricitabine/Tenofovir Disoproxil Fumarate in an Adolescent and Young Adult Female Population
CompletedNCT03593655
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections
Start: 2019-01-14End: 2021-09-09Updated: 2023-06-22

Phase 3

Phase 3 Safety and Effectiveness Trial of Dapivirine Vaginal Ring for Prevention of HIV-1 in Women
CompletedNCT01617096
International Partnership for Microbicides, Inc.HIV Infections
Start: 2012-07-24End: 2015-12-31Updated: 2022-12-21
Trial to Assess the Continued Safety of and Adherence to a Vaginal Ring Containing Dapivirine in Women
CompletedNCT02858037
International Partnership for Microbicides, Inc.Human Immunodeficiency Virus
Start: 2016-07-18End: 2018-10-10Updated: 2022-10-25

Related Papers

Adolescent Girls and Young Women Overcoming Adherence Challenges with Vaginal and Oral PrEP Use: A Longitudinal Qualitative Study from a Crossover Trial in South Africa, Uganda, and Zimbabwe
AIDS and Behavior2024-09-302 citations
Assessing Per-Sex-Act HIV-1 Risk Reduction Among Women Using the Dapivirine Vaginal Ring
The Journal of Infectious Diseases2023-12-142 citations
How a menu of adherence support strategies facilitated high adherence to HIV prevention products among adolescent girls and young women in sub‐Saharan Africa: a mixed methods analysis
Journal of the International AIDS Society2023-11-0121 citations
Adherence, safety, and choice of the monthly dapivirine vaginal ring or oral emtricitabine plus tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis among African adolescent girls and young women: a randomised, open-label, crossover trial.
2023-10-2542 citations
Adolescent Girls and Young Women's Experiences with Disclosing Oral PrEP or Dapivirine Vaginal Ring Use: a Multi-Country Qualitative Analysis.
2023-07-019 citations
Acceptability of the Dapivirine Vaginal Ring in Postmenopausal US Women
AIDS Patient Care and STDs2022-03-016 citations
Ethical considerations for involving adolescents in biomedical HIV prevention research
BMC Medical Ethics2021-09-2317 citations
Experiences with simultaneous use of contraception and the vaginal ring for HIV prevention in sub-Saharan Africa.
2021-04-232 citations
Acceptability of the Dapivirine Vaginal Ring for HIV-1 Prevention and Association with Adherence in a Phase III Trial.
2021-03-1332 citations
Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study.
2021-02-0193 citations
Sharing Objective Measures of Adherence to a Vaginal Microbicide Promotes Candor About Actual Use and Bolsters Motivation to Prevent HIV.
2020-09-123 citations
Vaginal Ring Use in a Phase 3 Microbicide Trial: A Comparison of Objective Measures and Self-reports of Non-adherence in ASPIRE.
2019-02-0112 citations
Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women
Clinical Infectious Diseases2018-08-0324 citations
Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women.
2016-02-22617 citations