Dalfampridine

DRUG11 trials

Conditions

FatigueIdiopathic Transverse MyelitisInternuclear OphthalmoplegiaMotor Neuron Disease, UpperMultiple SclerosisMyelitis NOSNeuromyelitis OpticaNon Arteritic Ischemic Optic Neuropathy

Early Phase 1

Effects of 4-AP on Functional SCI Recovery

CompletedNCT05447676

Shirley Ryan AbilityLabSpinal Cord Injury

Start: 2022-06-30End: 2025-06-30Updated: 2026-06-03

Phase 1

Use of Dalfampridine in Primary Lateral Sclerosis

Active, not recruitingNCT02868567

Hospital for Special Surgery, New YorkMotor Neuron Disease, Upper

Start: 2016-03-31End: 2026-07-31Target: 35Updated: 2025-09-11

Double Dose 4-AP on Functional Recovery After Spinal Cord Injury

RecruitingNCT06853015

Shirley Ryan AbilityLabSCI - Spinal Cord Injury

Start: 2025-02-01End: 2026-12-30Target: 27Updated: 2026-06-03

Phase 2

Dalfampridine for Imbalance in Multiple Sclerosis

CompletedNCT01444300

Oregon Health and Science UniversityFatigue, Multiple Sclerosis

Start: 2011-09-30End: 2013-09-30Updated: 2014-06-16

Combination Therapy With Dalfampridine and Locomotor Training for Chronic, Motor Incomplete Spinal Cord Injury

CompletedNCT01621113

Kessler FoundationSpinal Cord Injury

Start: 2012-06-30End: 2017-10-16Updated: 2017-12-02

Effects of Dalfampridine on Cognition in Multiple Sclerosis

CompletedNCT02006160

State University of New York at BuffaloMultiple Sclerosis

Start: 2011-12-31End: 2016-02-29Updated: 2020-10-01

Safety and Efficacy of Sustained Release Dalfampridine in Transverse Myelitis (Re-Launch)

CompletedNCT02166346

Johns Hopkins UniversityIdiopathic Transverse Myelitis, Myelitis NOS, Neuromyelitis Optica +1

Start: 2014-02-28End: 2017-01-08Updated: 2018-04-17

Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis

CompletedNCT02391961

VA Office of Research and DevelopmentFatigue, Internuclear Ophthalmoplegia, Multiple Sclerosis

Start: 2015-04-01End: 2019-03-31Updated: 2020-09-04

Effect of Dalfampridine (4-AP) on Genioglossus Muscle Activity in Healthy Adults

CompletedNCT02656160

Brigham and Women's HospitalSleep Apnea, Obstructive

Start: 2016-01-31End: 2016-07-31Updated: 2017-08-15

Phase 4

A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

CompletedNCT01975324

Neuro-Ophthalmologic Associates, PCNon Arteritic Ischemic Optic Neuropathy

Start: 2013-07-31End: 2015-12-31Updated: 2016-01-25

Unknown Phase

Dalfampridine and Gait in Spinocerebellar Ataxias

CompletedNCT01811706

University of FloridaSpinocerebellar Ataxias Type 1, Spinocerebellar Ataxias Type 2, Spinocerebellar Ataxias Type 3 +1

Start: 2013-02-28End: 2013-12-31Updated: 2015-01-12

Related Papers

Dalfampridine benefits ambulation but not cognition in multiple sclerosis

Multiple Sclerosis Journal2018-12-1921 citations

Effect of 4-Aminopyridine on Genioglossus Muscle Activity during Sleep in Healthy Adults

Annals of the American Thoracic Society2017-04-0724 citations