Copper

DRUG5 trials

Sponsors

University Hospital, Saarland, Olympion Medical Center, Sahlgrenska University Hospital, Daniel George, MD, National Cancer Institute, Slovakia

Conditions

Alzheimer´s DiseaseGlioblastomaGlioblastoma MultiformeGliomaMetastatic Breast CancerProstate Cancer

Phase 1

A Phase Ib Study of Intravenous Copper Loading With Oral Disulfiram in Metastatic, Castration Resistant Prostate Cancer

TerminatedNCT02963051

Daniel George, MDProstate Cancer

Start: 2017-07-11End: 2020-02-01Updated: 2021-09-16

Phase 2

Treatment With Copper in Patients With Mild Alzheimer´s Dementia

CompletedNCT00608946

University Hospital, SaarlandAlzheimer´s Disease

Start: 2004-03-31Updated: 2008-02-06

Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform

Not yet recruitingNCT01777919

Olympion Medical CenterGlioblastoma Multiforme

Start: 2027-01-31End: 2030-01-31Target: 32Updated: 2025-05-25

Disulfiram in Recurrent Glioblastoma

CompletedNCT02678975

Sahlgrenska University HospitalGlioblastoma, Glioma

Start: 2017-01-31End: 2021-01-15Updated: 2021-03-18

Vinorelbine, Cisplatin, Disulfiram and Copper in CTC_EMT Positive Refractory Metastatic Breast Cancer.

WithdrawnNCT04265274

National Cancer Institute, SlovakiaMetastatic Breast Cancer

Start: 2020-01-01End: 2023-01-01Updated: 2023-10-06

Related Papers

Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma

JAMA Network Open2023-03-3144 citations

Disulfiram (DSF) pharmacokinetics (PK) and copper PET imaging in a phase Ib study of intravenous (IV) copper loading with oral DSF for patients with metastatic castration-resistant prostate cancer (mCRPC).

Journal of Clinical Oncology2020-02-198 citations

Referee report. For: Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial [version 1; referees: 2 approved]

Faculty of 1000 Research Ltd2019-01-01

Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial.

2018-11-1524 citations

Referee report. For: Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial [version 1; referees: 1 approved]

Faculty of 1000 Research Ltd2018-01-01