Cohort A

DRUG8 trials

Conditions

Brain MetastasesBreast CancerChronic anemia due to ineffective erythropoiesis (IE) in subjects with ß thalassemia thalassemiaHealthyNonalcoholic SteatohepatitisObesityType 2 Diabetes MellitusUlcerative Colitis

Phase 1

Anti PD-1 Antibody With Radiation Therapy in Patients With HER2-negative Metastatic Breast Cancer

CompletedNCT03430479

Kyoto Breast Cancer Research NetworkBreast Cancer

Start: 2017-06-22End: 2021-04-01Updated: 2023-01-19

Phase II Study of FTD/TPI (Lonsurf) in Metastatic Breast Cancers With or Without Prior Exposure to Fluoropyrimidines (LONBRECA)

Active, not recruitingNCT04280536

National University Hospital, SingaporeBreast Cancer

Start: 2019-08-14End: 2026-06-30Target: 86Updated: 2025-09-23

To Evaluate the Safety, Tolerability, PK, and PD of XW003 Injection in Healthy Adult Participants

CompletedNCT04389775

Sciwind Biosciences APAC CO Pty. Ltd.Nonalcoholic Steatohepatitis, Obesity, Type 2 Diabetes Mellitus

Start: 2020-03-29End: 2021-09-29Updated: 2021-10-28

A Study to Investigate Efficacy and Safety of NSI-8226 in Healthy Participants

CompletedNCT06640920

Uniquity One (UNI)Healthy

Start: 2024-04-29End: 2024-10-29Updated: 2025-08-12

Phase 2

A Phase 2a, Randomized, Open-Label Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ISIS 702843 Administered Subcutaneously to Patients with Non-Transfusion Dependent ß-Thalassemia Intermedia

Active, not recruitingLBCTR2020071296

Ionis Pharmaceuticals, Inc.Chronic anemia due to ineffective erythropoiesis (IE) in subjects with ß thalassemia thalassemia

Start: 2020-02-17Target: 36Updated: 2026-02-02

Phase 4

Golimumab Dried Blood Spot Analysis

NCT02910375

Universitaire Ziekenhuizen KU LeuvenUlcerative Colitis

Start: 2016-12-31End: 2018-05-31Target: 10Updated: 2017-10-27

Unknown Phase

Pilot Phase 2 Study Whole Brain Radiation Therapy With Simultaneous Integrated Boost for Patients With Brain Metastases

TerminatedNCT03189381

Indiana UniversityBrain Metastases

Start: 2017-09-21End: 2022-09-30Updated: 2024-06-28

Personalization of Breast Radiotherapy According to Loco-regional Recurrence Risk and Toxicity Probability

RecruitingNCT06382818

Institut du Cancer de Montpellier - Val d'AurelleBreast Cancer

Start: 2025-03-06End: 2038-03-06Target: 854Updated: 2026-03-12

2023-06-2427 citations

Phase II study of trifluridine/tipiracil (FTD/TPI) in HER2-negative metastatic breast cancers with or without prior exposure to fluoropyrimidines.

Journal of Clinical Oncology2023-06-01

Phase Ib/II study of nivolumab combined with palliative radiation therapy for bone metastasis in patients with HER2-negative metastatic breast cancer.

2022-12-2715 citations

Predicting the efficacy of nivolumab combined with radiation therapy by longitudinal liquid biopsy with artificial intelligence for patients with metastatic breast cancer (translational research of the KBCRN-B-002 trial).

Journal of Clinical Oncology2020-05-20

Abstract P3-09-07: A multicenter phase Ib/II study for evaluating safety and efficacy of Nivolumab in combination with radiation therapy in patients with HER2-negative metastatic breast cancer (KBCRN-B-002 trial)

Cancer Research2020-02-151 citations

Abstract P4-10-33: Alteration of the tumor immune microenvironment signatures by nivolumab combined with radiation therapy for patients with metastatic breast cancer (Translational Research of the KBCRN-B-002 trial)

Cancer Research2020-02-15

Golimumab Dried Blood Spot Analysis (GOUDA): a Prospective Trial Showing Excellent Correlation with Venepuncture Samples and More Detailed Pharmacokinetic Information.

2018-12-1812 citations

P431 Golimumab dried blood spot analysis (GOUDA): A prospective trial to validate golimumab concentration analysis using the dried blood spot methodology

Journal of Crohn s and Colitis2018-01-16