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Cohort A

DRUG9 trials

Sponsors

Ionis Pharmaceuticals, Inc., Universitaire Ziekenhuizen KU Leuven, Indiana University, Kyoto Breast Cancer Research Network, National University Hospital, Singapore

Conditions

Brain MetastasesBreast CancerChronic anemia due to ineffective erythropoiesis (IE) in subjects with ß thalassemia thalassemiaHealthyNonalcoholic SteatohepatitisObesityOvarian CancerType 2 Diabetes Mellitus

Phase 1

Anti PD-1 Antibody With Radiation Therapy in Patients With HER2-negative Metastatic Breast Cancer
CompletedNCT03430479
Kyoto Breast Cancer Research NetworkBreast Cancer
Start: 2017-06-22End: 2021-04-01Updated: 2023-01-19
Phase II Study of FTD/TPI (Lonsurf) in Metastatic Breast Cancers With or Without Prior Exposure to Fluoropyrimidines (LONBRECA)
Active, not recruitingNCT04280536
National University Hospital, SingaporeBreast Cancer
Start: 2019-08-14End: 2026-06-30Target: 86Updated: 2025-09-23
To Evaluate the Safety, Tolerability, PK, and PD of XW003 Injection in Healthy Adult Participants
CompletedNCT04389775
Sciwind Biosciences APAC CO Pty. Ltd.Nonalcoholic Steatohepatitis, Obesity, Type 2 Diabetes Mellitus
Start: 2020-03-29End: 2021-09-29Updated: 2021-10-28
A Study to Investigate Efficacy and Safety of NSI-8226 in Healthy Participants
CompletedNCT06640920
Uniquity One (UNI)Healthy
Start: 2024-04-29End: 2024-10-29Updated: 2025-08-12

Phase 2

A Phase 2a, Randomized, Open-Label Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ISIS 702843 Administered Subcutaneously to Patients with Non-Transfusion Dependent ß-Thalassemia Intermedia
Active, not recruitingLBCTR2020071296
Ionis Pharmaceuticals, Inc.Chronic anemia due to ineffective erythropoiesis (IE) in subjects with ß thalassemia thalassemia
Start: 2020-02-17Target: 36Updated: 2026-02-02
Chemotherapy Combined With Propranolol Hydrochloride as Neoadjuvant Therapy for Advanced High-grade Serous Ovarian Cancer
RecruitingNCT07125391
Bai-Rong XiaOvarian Cancer
Start: 2025-06-20End: 2027-06-30Target: 40Updated: 2025-08-15

Phase 4

Golimumab Dried Blood Spot Analysis
NCT02910375
Universitaire Ziekenhuizen KU LeuvenUlcerative Colitis
Start: 2016-12-31End: 2018-05-31Target: 10Updated: 2017-10-27

Unknown Phase

Pilot Phase 2 Study Whole Brain Radiation Therapy With Simultaneous Integrated Boost for Patients With Brain Metastases
TerminatedNCT03189381
Indiana UniversityBrain Metastases
Start: 2017-09-21End: 2022-09-30Updated: 2024-06-28
Personalization of Breast Radiotherapy According to Loco-regional Recurrence Risk and Toxicity Probability
RecruitingNCT06382818
Institut du Cancer de Montpellier - Val d'AurelleBreast Cancer
Start: 2025-03-06End: 2038-03-06Target: 854Updated: 2026-03-12

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