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Cemdisiran

DRUG18 trials

Sponsors

Regeneron Pharmaceuticals Inc., Alnylam Pharmaceuticals, Mario Negri Institute for Pharmacological Research, Regeneron Pharmaceuticals

Conditions

Age-related Macular Degeneration (AMD)Atypical Hemolytic Uremic SyndromeBerger DiseaseGeneralized Myasthenia GravisGeographic Atrophy (GA)Geographic Atrophy Secondary to Age-Related Macular DegenerationGlomerulonephritis, IgAHealthy

Phase 1

Phase 2

Phase 3

A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis
Active, not recruitingNCT05070858
Regeneron PharmaceuticalsGeneralized Myasthenia Gravis
Start: 2021-12-14End: 2028-11-11Updated: 2026-02-12
Efficacy and Safety of the Combination of Pozelimab and Cemdisiran Versus Continued Eculizumab or Ravulizumab Treatment in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria
TerminatedNCT05131204
Regeneron PharmaceuticalsParoxysmal Nocturnal Hemoglobinuria
Start: 2022-10-06End: 2023-07-12Updated: 2025-04-08
A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment
RecruitingNCT05133531
Regeneron PharmaceuticalsParoxysmal Nocturnal Hemoglobinuria
Start: 2022-08-01End: 2027-01-28Target: 190Updated: 2026-02-24
A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works
RecruitingNCT05744921
Regeneron PharmaceuticalsParoxysmal Nocturnal Hemoglobinuria
Start: 2023-03-07End: 2029-02-26Target: 202Updated: 2026-03-18
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
RecruitingNCT06541704
Regeneron PharmaceuticalsAge-related Macular Degeneration (AMD), Geographic Atrophy (GA)
Start: 2024-10-30End: 2032-05-21Target: 975Updated: 2026-03-23
An Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of Pozelimab and Cemdisiran Combination Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria
RecruitingCTIS2023-510336-36-00
Regeneron Pharmaceuticals Inc.Paroxysmal nocturnal hemoglobinuria (PNH)
Start: 2023-05-05Target: 17Updated: 2025-11-04
A Randomized, Open-Label, C5 Inhibitor-Controlled Study to Evaluate the Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria who are Complement Inhibitor Treatment-Naive or Have Not Recently Received Complement Inhibitor Therapy
RecruitingCTIS2023-509657-31-00
Regeneron Pharmaceuticals Inc.Paroxysmal nocturnal haemoglobinuria (PNH)
Start: 2022-08-24Target: 17Updated: 2025-11-10
A Multicenter, Randomized, Double-Masked, Placebo-Controlled Phase 3 Study of the Efficacy, Safety, and Tolerability of Subcutaneously Administered Pozelimab in Combination with Cemdisiran or Cemdisiran Alone in Participants with Geographic Atrophy Secondary to Age-Related Macular Degeneration
RecruitingCTIS2023-509547-27-00
Regeneron Pharmaceuticals Inc.Geographic Atrophy Secondary to Age-Related Macular Degeneration
Start: 2025-05-22Target: 464Updated: 2026-01-19
A Study to Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working Efficiently
RecruitingNCT07154745
Regeneron PharmaceuticalsParoxysmal Nocturnal Hemoglobinuria
Start: 2026-03-31End: 2031-09-23Target: 35Updated: 2026-03-19
A Single Arm Study to Evaluate the Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria with Inadequate Control of Intravascular Hemolysis on Currently Available C5 Inhibitor Therapy
Not yet recruitingCTIS2024-519709-37-00
Regeneron Pharmaceuticals Inc.Paroxysmal nocturnal hemoglobinuria (PNH)
Target: 8Updated: 2025-11-28

Unknown Phase

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