Calquence 100 mg film-coated tablets
Sponsors
University Of Saarland, AstraZeneca AB, Astrazeneca AB, University Of Cologne, Ascentage Pharma Group Inc.
Conditions
Chronic Lymphocytic LeukaemiaChronic Lymphocytic Leukaemia and Moderate to Severe Cardiac ImpairmentChronic Lymphocytic LeukemiaChronic Lymphocytic Leukemia or Small Lymphocytic LymphomaChronic Lymphocytic Leukemia/Small Lymphocytic LymphomaDisseminated large B-cell lymphomaHigh Risk Chronic Lymphocytic LeukaemiaIndolent B-Cell Non-Hodgkin Lymphoma
Phase 1
Phase 1/2a Clinical Trial of BI-1206, a Monoclonal Antibody to CD32b (FcyRIIB), in Combination with Rituximab With or Without Acalabrutinib in Subjects with Indolent B-Cell Non-Hodgkin Lymphoma That Has Relapsed or is Refractory to Rituximab
RecruitingCTIS2024-512972-36-00
Start: 2019-05-23Target: 23Updated: 2025-06-30
A Phase 1/2, Multicenter, Open-label, and Dose-escalation Study of ACP-196 in Subjects with Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia
Active, not recruitingCTIS2023-509346-35-00
Start: 2015-05-26Target: 1Updated: 2025-12-15
An Open-label, Phase 1b/2 Study of Acalabrutinib Alone or in Combination Therapy in Subjects with B-cell Non-Hodgkin Lymphoma
Active, not recruitingCTIS2023-509350-63-00
Start: 2020-09-16Target: 2Updated: 2025-09-17
A Phase I/II Open-Label Multi-Centre Master Protocol to Evaluate the Safety and Efficacy of AZD0486 Monotherapy or in Combination with Other Anticancer Agents in Participants with Mature B-Cell Malignancies
Substudy 1: Chronic Lymphocytic Leukaemia and Small Lymphocytic Lymphoma
Substudy 2: Mantle Cell Lymphoma
Substudy 3: Large B-Cell Lymphoma
RecruitingCTIS2024-515034-33-00
Start: 2025-03-05Target: 200Updated: 2025-11-25
Phase 2
A Multicentre, Phase II, Open-label Study to Evaluate the Efficacy of Acalabrutinib in Combination with Venetoclax and Rituximab in Participants with Treatment Naïve Mantle Cell Lymphoma (TrAVeRse)
Active, not recruitingCTIS2023-505205-16-00
Start: 2024-02-21Target: 41Updated: 2025-07-18
CLL-Frail - A prospective, multicenter phase II trial of acalabrutinib in very old (≥80y) or frail CLL-Patients
CompletedCTIS2023-507002-14-00
Start: 2021-05-20End: 2025-05-08Target: 53Updated: 2025-03-10
An Open-label, Phase 2 Study of ACP-196 in Subjects with Mantle Cell Lymphoma
CompletedCTIS2023-509352-34-00
Start: 2015-06-18End: 2025-11-03Target: 3Updated: 2025-10-02
An Open-label, Phase 2 Study of ACP-196 in Subjects with Waldenström Macroglobulinemia
Active, not recruitingCTIS2023-509356-34-00
Start: 2015-09-28Target: 6Updated: 2025-09-25
SAKK 38/19: Assessing a ctDNA and PET-oriented therapy in patients with DLBCL. A multicenter, open-label, phase II trial
Not yet recruitingCTIS2024-516740-26-00
Target: 104Updated: 2025-06-04
FILOCLL14 - STAIR : "Open-label, phase 2 study investigating the STop and restart Acalabrutinib In fRrail patients with previously untreated CLL (STAIR)"
Active, not recruitingCTIS2024-513936-80-00
Start: 2021-11-12Target: 160Updated: 2025-12-01
A Prospective, Open-Label, Phase IIb/III Study to Evaluate the Risk of TLS and Optimization of the Initiation of Venetoclax in Combination with Obinutuzumab or Acalabrutinib With Different Ramp-Up Periods in Previously Untreated Subjects with CLL
Active, not recruitingCTIS2024-512147-23-00
Start: 2024-11-21Target: 161Updated: 2025-11-04
The SOUND-MCL study: A single-arm, open-label, multicenter, phase II study of acalabrutinib, in combination with the R-CHOP standard of care, for previously untreated mantle cell lymphoma in Spain
RecruitingCTIS2025-521152-34-00
Start: 2025-09-04Target: 55Updated: 2025-09-29
Phase 3
A Randomized, Open-label, Phase 3 Study of Acalabrutinib in Combination with Rituximab and Reduced Dose CHOP (R-miniCHOP) in Older Adults with Untreated Diffuse Large B-Cell Lymphoma (ARCHED/GLA 2022-1)
RecruitingCTIS2022-501187-18-00
Start: 2023-04-24Target: 360Updated: 2025-11-04
A Phase III Prospective, Multicenter, Randomized, Open-Label Trial of Acalabrutinib plus Venetoclax versus Venetoclax plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Active, not recruitingCTIS2023-505866-27-00
Start: 2022-10-28Target: 387Updated: 2025-10-21
A Global Multicenter, Open Label, Randomized Phase 3 Registrational Study of Lisaftoclax (APG-2575) in Previously Treated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (GLORA Study)
RecruitingCTIS2023-508005-24-00
Start: 2024-08-01Target: 232Updated: 2025-12-03
A Randomized, Multicenter, Open-Label, Non-Inferiority, Phase 3 Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects with High Risk Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509347-27-00
Start: 2015-09-30Target: 17Updated: 2025-09-30
A Randomized, Multicenter, Open-Label, 3 Arm Phase 3 Study of Obinutuzumab in Combination with Chlorambucil, ACP 196 in Combination with Obinutuzumab, and ACP-196 Monotherapy in Subjects with Previously Untreated Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509348-84-00
Start: 2015-04-27Target: 212Updated: 2025-12-22