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Calquence 100 mg film-coated tablets

DRUG18 trials

Sponsors

University Of Saarland, AstraZeneca AB, Astrazeneca AB, University Of Cologne, Ascentage Pharma Group Inc.

Conditions

Chronic Lymphocytic LeukaemiaChronic Lymphocytic Leukaemia and Moderate to Severe Cardiac ImpairmentChronic Lymphocytic LeukemiaChronic Lymphocytic Leukemia or Small Lymphocytic LymphomaChronic Lymphocytic Leukemia/Small Lymphocytic LymphomaDisseminated large B-cell lymphomaHigh Risk Chronic Lymphocytic LeukaemiaIndolent B-Cell Non-Hodgkin Lymphoma

Phase 1

Phase 1/2a Clinical Trial of BI-1206, a Monoclonal Antibody to CD32b (FcyRIIB), in Combination with Rituximab With or Without Acalabrutinib in Subjects with Indolent B-Cell Non-Hodgkin Lymphoma That Has Relapsed or is Refractory to Rituximab
RecruitingCTIS2024-512972-36-00
BioInvent International ABIndolent B-Cell Non-Hodgkin Lymphoma
Start: 2019-05-23Target: 23Updated: 2025-06-30
A Phase 1/2, Multicenter, Open-label, and Dose-escalation Study of ACP-196 in Subjects with Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia
Active, not recruitingCTIS2023-509346-35-00
Acerta Pharma B.V.Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, Richter's Syndrome
Start: 2015-05-26Target: 1Updated: 2025-12-15
An Open-label, Phase 1b/2 Study of Acalabrutinib Alone or in Combination Therapy in Subjects with B-cell Non-Hodgkin Lymphoma
Active, not recruitingCTIS2023-509350-63-00
Acerta Pharma B.V.Relapsed/Refractory marginal zone lymphoma
Start: 2020-09-16Target: 2Updated: 2025-09-17
A Phase I/II Open-Label Multi-Centre Master Protocol to Evaluate the Safety and Efficacy of AZD0486 Monotherapy or in Combination with Other Anticancer Agents in Participants with Mature B-Cell Malignancies Substudy 1: Chronic Lymphocytic Leukaemia and Small Lymphocytic Lymphoma Substudy 2: Mantle Cell Lymphoma Substudy 3: Large B-Cell Lymphoma
RecruitingCTIS2024-515034-33-00
AstraZeneca ABChronic Lymphocytic Leukaemia, Large B-Cell Lymphoma, Mantle Cell Lymphoma +1
Start: 2025-03-05Target: 200Updated: 2025-11-25

Phase 2

A Multicentre, Phase II, Open-label Study to Evaluate the Efficacy of Acalabrutinib in Combination with Venetoclax and Rituximab in Participants with Treatment Naïve Mantle Cell Lymphoma (TrAVeRse)
Active, not recruitingCTIS2023-505205-16-00
AstraZeneca ABTreatment Naïve Mantle Cell Lymphoma
Start: 2024-02-21Target: 41Updated: 2025-07-18
CLL-Frail - A prospective, multicenter phase II trial of acalabrutinib in very old (≥80y) or frail CLL-Patients
CompletedCTIS2023-507002-14-00
University Of Colognetreatment-naïve or relapsed/refractory chronic lymphocytic leukemia
Start: 2021-05-20End: 2025-05-08Target: 53Updated: 2025-03-10
An Open-label, Phase 2 Study of ACP-196 in Subjects with Mantle Cell Lymphoma
CompletedCTIS2023-509352-34-00
Acerta Pharma B.V.Mantle Cell Lymphoma
Start: 2015-06-18End: 2025-11-03Target: 3Updated: 2025-10-02
An Open-label, Phase 2 Study of ACP-196 in Subjects with Waldenström Macroglobulinemia
Active, not recruitingCTIS2023-509356-34-00
Acerta Pharma B.V.Waldenström Macroglobulinemia
Start: 2015-09-28Target: 6Updated: 2025-09-25
SAKK 38/19: Assessing a ctDNA and PET-oriented therapy in patients with DLBCL. A multicenter, open-label, phase II trial
Not yet recruitingCTIS2024-516740-26-00
Swiss Group for Clinical Cancer ResearchDisseminated large B-cell lymphoma
Target: 104Updated: 2025-06-04
FILOCLL14 - STAIR : "Open-label, phase 2 study investigating the STop and restart Acalabrutinib In fRrail patients with previously untreated CLL (STAIR)"
Active, not recruitingCTIS2024-513936-80-00
French Innovative Leukemia Organizationelderly patients (> 70 years) with CLL or SLL
Start: 2021-11-12Target: 160Updated: 2025-12-01
A Prospective, Open-Label, Phase IIb/III Study to Evaluate the Risk of TLS and Optimization of the Initiation of Venetoclax in Combination with Obinutuzumab or Acalabrutinib With Different Ramp-Up Periods in Previously Untreated Subjects with CLL
Active, not recruitingCTIS2024-512147-23-00
AbbVie Deutschland GmbH & Co. KGChronic Lymphocytic Leukemia
Start: 2024-11-21Target: 161Updated: 2025-11-04
The SOUND-MCL study: A single-arm, open-label, multicenter, phase II study of acalabrutinib, in combination with the R-CHOP standard of care, for previously untreated mantle cell lymphoma in Spain
RecruitingCTIS2025-521152-34-00
Astrazeneca Farmaceutica Spain S.A.mantle cell lymphoma (MCL)
Start: 2025-09-04Target: 55Updated: 2025-09-29

Phase 3

A Randomized, Open-label, Phase 3 Study of Acalabrutinib in Combination with Rituximab and Reduced Dose CHOP (R-miniCHOP) in Older Adults with Untreated Diffuse Large B-Cell Lymphoma (ARCHED/GLA 2022-1)
RecruitingCTIS2022-501187-18-00
University Of Saarlanda. Diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS), b. Primary cutaneous DLBCL leg type, c. Intravascular large B-cell lymphoma +13
Start: 2023-04-24Target: 360Updated: 2025-11-04
A Phase III Prospective, Multicenter, Randomized, Open-Label Trial of Acalabrutinib plus Venetoclax versus Venetoclax plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Active, not recruitingCTIS2023-505866-27-00
Astrazeneca ABChronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Start: 2022-10-28Target: 387Updated: 2025-10-21
A Global Multicenter, Open Label, Randomized Phase 3 Registrational Study of Lisaftoclax (APG-2575) in Previously Treated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (GLORA Study)
RecruitingCTIS2023-508005-24-00
Ascentage Pharma Group Inc.Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Start: 2024-08-01Target: 232Updated: 2025-12-03
A Randomized, Multicenter, Open-Label, Non-Inferiority, Phase 3 Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects with High Risk Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509347-27-00
Acerta Pharma B.V.High Risk Chronic Lymphocytic Leukaemia
Start: 2015-09-30Target: 17Updated: 2025-09-30
A Randomized, Multicenter, Open-Label, 3 Arm Phase 3 Study of Obinutuzumab in Combination with Chlorambucil, ACP 196 in Combination with Obinutuzumab, and ACP-196 Monotherapy in Subjects with Previously Untreated Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509348-84-00
Acerta Pharma B.V.Chronic Lymphocytic Leukemia
Start: 2015-04-27Target: 212Updated: 2025-12-22

Phase 4

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