Calaspargase pegol-mknl

DRUG4 trials

Sponsors

Children's Oncology Group, West Virginia University, OHSU Knight Cancer Institute, M.D. Anderson Cancer Center

Conditions

Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAdult B Acute Lymphoblastic LeukemiaChildhood B Acute Lymphoblastic LeukemiaLocally Advanced Pancreatic AdenocarcinomaMetastatic Pancreatic AdenocarcinomaStage II Pancreatic Cancer AJCC v8Stage IIA Pancreatic Cancer AJCC v8

Phase 1

Phase 1 of Calaspargase Pegol-mknl W/ Cytarabine and Idarubicin in Newly Diagnosed AML

Active, not recruitingNCT04953780

West Virginia UniversityAcute Myeloid Leukemia

Start: 2021-09-27End: 2030-02-01Updated: 2026-09-02

Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

CompletedNCT05034627

OHSU Knight Cancer InstituteLocally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma, Stage IIA Pancreatic Cancer AJCC v8 +4

Start: 2022-08-09End: 2026-06-03Updated: 2026-07-23

Phase 2

A Phase 2 Study to Evaluate Efficacy of Calaspargase Pegol-mknl and Decitabine Combined With Venetoclax in Pediatric, Adolescent, and Young Adult Patients With Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia (T-ALL) and T- Cell Lymphoblastic Lymphoma (T-LLy)

RecruitingNCT06561074

M.D. Anderson Cancer CenterT-cell Acute Lymphoblastic Leukemia, T-Cell Lymphoblastic Lymphoma

Start: 2025-09-25End: 2031-12-31Target: 22Updated: 2026-09-18

Phase 3

Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

CompletedNCT00671034

Children's Oncology GroupAcute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia, Childhood B Acute Lymphoblastic Leukemia

Start: 2008-07-21End: 2021-03-31Updated: 2021-04-27

Related Papers

CASPER: A Phase I trial combining calaspargase pegol-mnkl and cobimetinib in pancreatic cancer

Future Oncology2024-10-082 citations

Casper: A phase I, open-label, dose finding study of calaspargase pegol-mnkl (cala) in combination with cobimetinib (cobi) in locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC).

Journal of Clinical Oncology2023-01-242 citations

Erwinia asparaginase (crisantaspase) increases plasma levels of serine and glycine

Frontiers in Oncology2022-12-124 citations

Plasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children’s Oncology Group AALL07P4

Leukemia & lymphoma/Leukemia and lymphoma2019-01-1041 citations

Plasma asparaginase activity and asparagine depletion in patients with acute lymphoblastic leukemia (ALL) treated with pegaspargase (SS-PEG <i>E. coli</i> L-asparaginase): Results from Children’s Oncology Group (COG) study AALL07P4.

Journal of Clinical Oncology2016-05-203 citations